Plasma Homocysteine Levels In Patients With Essential Hypertension And The Relationship Between Tcm Syndrome Type

[Objective] Research on the regularities of distribution of TCM syndrome types and the relationships between TCM syndrome types, levels of plasma homocysteine(HCY), abnormality of blood-lipid, BMIs and abdominal circumferences in inpatients with essential hypertension, in order to provide objective evidence for TCM syndrome differentiation of hypertension, and to improve the clinical treatment effect of traditional Chinese medicine.[Methods] According to "the Chinese herbal medicine clinical research guiding principles",260inpatients with essential hypertension were categorized into four groups:overabundant liver-fire group, hyperactivity of yang due to yin deficiency group, excessive damp-phlegm group and deficiency of both yin and yang group. The level of plasma HCY was measured by euzyme linked immunosorbent assay. All statistical data was analyzed by using SPSS software version18.0.[Result] The sample sizes of different TCM syndrome types were as following: hyperaetivity of yang due to yin deficiency group (77)> excessive damp-phlegm group (73)> overabundant liver-fire group (56)> deficiency of both yin and yang group (54). The levels of plasma HCY were statistically significantly different in the four TCM syndrome type groups. Level of plasma HCY in excessive damp-phlegm group was the highest. The prevalence rate of hyperhomocystinemia(HHcy) in male patients with essential hypertension was higher than that in female. The prevalence rate of blood lipid abnormality in excessive damp-phlegm group was the highest. BMI in excessive damp-phlegm group was higher than that in both overabundant liver-fire group and deficiency of both yin and yang group (P<0.05). Abdominal circumference in excessive damp-phlegm group was higher than that in deficiency of both yin and yang group(P<0.05) and hyperactivity of yang due to yin deficiency group(P<0.01).[Conclusion] Excessive damp-phlegm syndrome of essential hypertension must be attached more importance, because this distribution ratio in the four TCM syndrome types was high, and it had a lot to do with the risk factors that lead to or affect essential hypertension, such as abnormality of blood lipid, obesity, HHcy and so on.