Tcm Constitution Type Of Breast Cancer Clinical Research And Molecular Classification Relationship

This article includes a review and clinical research in two parts.Literature review of two articles:the first review reviews the recent development of constitution theory in TCM, in the basic and clinical aspects of the research, mainly from the Constitution and malignant tumor incidence, treatment, prognosis, prevention are discussed in this paper, constitution of traditional Chinese "differentiation-disease-dialectical" the Trinity clinic model.Current breast cancer medicine research is opposite less, constitution and breast cancer prevention and treatment remains to be further studied.A second review review of breast cancer molecular typing of the development process, the research status at home and abroad, the molecular typing of clinical characteristics and therapeutic and prognostic relation.Clinical study of patients with breast cancer:Objective:to analyze the characteristics of TCM constitution types, and molecular typing of the relationship, and tried to explore the TCM differentiation of breast cancer therapeutic advantage group.Methods:by way of questionnaire survey to collect breast cancer patients physical data, and according to the postoperative pathological and molecular typing, using SPSS20.0statistical software, using cross table test, analysis of breast cancer patients with physical characteristics, molecular typing and physical types of relevance.Results:In118cases with the group of patients with breast cancer, TCM constitution types to biased constitution overall majority, the Constitution Types in Yang-deficiency constitution, Qi-stagnation constitution, flat and quality, with quality the highest proportion.In patients with breast cancer molecular typing between physical type distribution with statistical difference (P<0.05, C>0.5). Luminal A patients, the qi depression quality, level and quality; Luminal type B patients with Yang deficiency, quality, and quality, phlegm damp material; type Basal-Like patients. Yang, qi stagnation quality, deficiency of Yin material; type HLR2patients with Yang deficiency, quality, quality, quality of qi deficiency and blood stasis.A combine physique types were divided into five groups: Group (Yang deficient constitution. Yin Qi quality quality quality, phlegm and blood stasis), wet group (Tanshi, damp-heat, blood stasis matter matter). Qi-stagnation constitution group, special quality, level and quality of intrinsic group group, the five groups of physical and molecular typing there is also a correlation (P<0.05, C>0.5). in which Luminal B type and HER2type in the phlegm wet group the proportion is higher. Lumianl A Xing Ping and matter more; the molecular typing of clinical characteristics arc not the same, Luminal A type and HER2type, Luminal type B compared with small diameter, mass, lymph node metastasis number, earlier clinical staging, risk stratification is low (P<0.05), and Luminal B type and HER2type with tumor diameter is larger, the number of lymph node metastases, clinical staging, risk stratification in later high (P<0.05).Conclusion:①Most of the breast cancer patients are biased Constitutions, in which,Yang asthenia matter, Qi-stagnation constitution, the constitution of yin-yang harmony are the highest proportion tyepes;②Breast cancer molecular classifications and constitution types have the connection, The constitution of yin-yang harmony has the highest proportion in the Luminal A type patients, which has better prognosis, the constitution types of phlegm-dampness, blood stasis, damp heat and Luminal B type and HER2type are closely related;③Breast cancer molecular typing of clinical characteristics of different, Luminal A stage, prognosis is better, Luminal B type and HER2type a Luminal type A late stage, the prognosis is poor; the Luminal A type and Luminal type B secretion or choice of treatment chemotherapy and endocrine therapy; type HER2and three negative breast cancer with TCM phlegm, blood stasis, wet body closely, and modern medicine to treat certain limitations exist, it can be used as traditional Chinese medicine therapeutic advantage crowd further discussion.