Clinical Observation On Erbantang In The Treatment Of Chronic Glomerulonephritis (Insufficiency Of Both Qi And Yin Syndrome With Heat-toxiciyt)

Chronic nephritis is a common chronic kidney disease. It makesslow progress which is accompanied by recurrent attacks of edema,proteinuria, hematuria,hypertension. The major cause is suggested tobe the Chronic renal failure by the Chronic nephritis.Objective:To evaluate the effect of Erbantang made by the Professor Guanjinghuan on chronic nephritis (insufficiency of both qi and Yinsyndrome with heat-toxicity).Methods：1.60cases patients were hospitalized and outpatient in Chinese andWestern Medicine Hospital in Wuhan from March in2012to Marchin2013.They were diagnosed chronic glomerulo nephritis(insufficiency of both qi and Yin syndrome with heat-toxicity),according to the"Chinese medicine clinical research drug treatmentguidelines for chronic nephritis"(Trial) inclusion and exclusioncriteria for case selection.2.60cases were divided into two groups at randomly, the treatmentgroup of30patients,the control group of30patients,. 3. To adopt prospective，randomized，controlled trial design.60patientswere assigned to two groups，the30patients in the treated groupwith erbantang plus traditional methods and the30in the controlgroup treated with nephritis rehabilitation tablets plus traditionalmethods for8weeks.4. Observed continuously for change of clinical symptoms，URT,24h-Upro，kidney functions,albumin，and change of securityindicator before and after the treatment.Result:1. Two groups of patients before treatment generally (include age,gender, kidney function, anemia index) compare, was not statisticallysignificant (P>0.05), comparable.2.The total efficiency of the treatment group is83.33％，and63.33％forthat of the control group，which indicates that the treatment effect ofthe treatment group is obviouslybetter than the control group with sense of statistics (P<O．05).3. Comparison of traditional Chinese medicine syndromes between thetwo groups: The total efficiency of the treatment group is86.67％，and66.67％for the control group.There was a significantdifference between the two groups (P<0.05), the treatment groupbetter than the control group.4．There was not a significant difference between the two groups(P>0.05)between the total score in symptom improvement of the twogroups before the treatment.In terms of total score in symptomimprovement，the two groups both have an obvious improvementcompared with the status before treatment (P<0.05or0．01).Compared with the control group, symptoms were statisticallysignificant (P <0.05) except red yellow urine and Lumbar pain. 5. Comparison of Laboratory indices：comparison of two group beforeand after treatment: routine urine test (Qualitative urine protein,Urine RBC)，24-hour urinary protein, Renal function test(blood ureanitrogen, creatinine), albumin were significant differences (P <0.05or0.01). Comparison after treatment between two groups: thetreatment group has all improvement in24一hour urinary protein，Urine RBC, albumin compared with the status before treatment(P<O．05)and has a better improvement than the controlgroup(P<O．05).It has no improvement in Qualitative urine protein,blood urea nitrogen, serum creatinine compared with the controlgroup was not significant (P>0.05).6.Adverse reactions: during the treatment, just two patients in treatmentgroup were stomach pain.They finished all the treatment after drugadjusted.The other patients was no significant damage to liver andkidney function and side effects.Conclusion：Erbantang has the effective to reduce chronic nephritis(insufficiency of both qi and Yin syndrome with heat-toxicity).It can improve serum albumin, lower serum creatinine and blood ureanitrogen, and improve renal function.It obviously improves the totalefficiency and the total score in symptom improvement.