| Chronic nephritis is a set with hematuria and proteinuria, hypertension and edema asclinical manifestations of Chronic kidney disease,whose character is slow progress andeasy to replase.It may be accompanied with varying degrees of renal function impairment.Objective To evaluate the effect and security of Manshenheji made by the Professor YuHaiyuan on chronic nephritis. Search for more effective characteristic of traditionalChinese medicine treatment on chronic nephritis. And explore its mechanism by thephysical and biochemical indicators around the treatment.Methods1.60cases patients were hospitalized and outpatient in YanTai Hospital of TCMfrom November in2012to November in2013.They were diagnosed chronic glomerulonephritis,according to “Western medicine diagnostic criteria of CGN in The summary ofcolloquia on treatment and classification and diagnostic criteria of primary glomerulopathydetermined by Chinese Journal of Internal Medicine Editorial board,June,1992” forcase selection.2.60cases were divided into two groups at randomly, the treatment group of30patients,the control group of30patients.3. To adopt prospective,randomized,controlled trial design.60patientswere assigned to two groups，the30patients in the treated group with erbantang plustraditional methods and the30in the control group treated with nephritis rehabilitation tablets plus traditional methods for8weeks.4. Observed continuously for change of clinical symptoms，U RT,24h一U pro，kidneyfunctions, T-lymphocyte subsets，and change of security indicator before and after thetreatment.Result:1.Two groups of patients before treatment generally (include age,gender, kidneyfunction，anemia index) compare, was not statistically significant (P>0.05), comparable.2.The total efficiency of the treatment group is83.33%,and63.33%for that of the controlgroup，which indicates that the treatment effect of the treatment group is obviously betterthan the control group witn sense of statistics (P＜0.05).3. Comparison of traditional Chinese medicine syndromes between the two groups:Thetotal efficiency of the treatment group is86.67%， and66.67%for the controlgroup.There was a significant difference between the two groups (P<0.05)，the treatmentgroup better than the control group.There was not a significant difference between the twogroups(P>0.05)between the total score in symptom improvement of the two groups beforethe treatment.In terms of total score in symptom improvement，the two groups both havean obvious improvement compared with the status before treatment (P<0.05or0.01).Compared with the control group, symptoms were statistically significant (P<0.05).4. Comparison of Laboratory indices:comparison of two group before and after treatment:routine urine test (Urine RBC)，24一hour urinary protein，Renal function test(blood ureanitrogen，creatinine), albumin were significant differences (P <0.05or0.01).Comparisonafter treatment between two groups:the treatment group has all improvement in24一hoururinary protein，Urine RBC，T-lymphocyte subsets compared with the status beforetreatment(P<0..05)and has a better improvement than the control group(P<O.05).1t has noimprovement in Qualitative urine protein， blood urea nitrogen， serum creatininecompared with the control group was not significant (P>0.05).5.Adverse reactions: during the treatment, just two patients in treatmentgroup were stomach pain.They finished all the treatment after drug adjusted.The otherpatients was no significant damage to liver and kidney function and side effects. Conclusion Manshenheji has the curative effect to CGN，and be adjusted to differentsymptoms. It improves serum albumin，lower serum creatinine and blood ureanitrogen，and improve renal function，adjust the immune function in patients and obviouslyimproves the total efficiency and the total score in symptom improvement which is worthpromoting In the clinical. |
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