Prevalence And Influence Factors Of Microalbuminuria In Middle-aged And Elder With Impaired Glucose Metabolism

Objective To explore the prevalence of microalbuminuria (MAU) in middle-aged and elderly with impaired glucose regulation(IGR) and type2diabetes mellitus (T2DM) and to investigate the risk factors for the development of MAU.Methods A random sampling study was conducted in Lanzhou Wuquantieluxicun community with a representative sample of2960adults aged above40years. Questionnaire was conducted. Height, weight, waist circumference(WC), hip circumference, blood pressure, fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2hPG), blood lipid, urinary albumin and urine creatinine were determined,and to calculate ACR(albumin to creatinine ratio).Results1. Of the2,960subjects,after adjusted age and gender, the prevalence of IGR and T2DM was21.0%,17.6%, the prevalence in male and female increased with age (IGR: P=0.016in male and P<0.0001in female; T2DM:both P<0.0001in male and female). There was no significant differences in the prevalence of IGR among male and female (χ=-0.924, P=0.283); However, the incidence of T2DM in male was significantly higher than that of the female (χ2=16.25,P=0.0006).2. Age-standardized prevalence of MAU in IGR group (n=682) and T2DM group (n=623) was8.1%and19.5%respectively, T2DM group had significantly higher prevalence of MAU compared with IGR group (χ2=19.28,P<0.001). Male had a significantly higher prevalence of MAU in IGR group (9.0%versus7.7%;χ2=2.16,P<0.01).3. With the exception of LDL-C, TC or drinking, in IGR and T2DM groups with or without MAU, there were significant differences in the other statistical index (P<0.05). Among IGR population, HbA1c, WC, SBP, DBF in people with MAU was significantly higher than those without MAU, but the level of movement was lower (P<0.05); And in T2DM group. IPG,2hPG, HbA1c, duration of T2DM, BMI, WC, WHR, SBP, DBP in those who had MAU was higher than who did not (P<0.05).4. The prevalence of MAU showed statistically significant difference between people taking different hypoglycemic drugs (P<0.05).The prevalence of MAU among people who took two or more medicines (combined with insulin), insulin, drugs promoting insulin (sulfonylureas and non-sulfonylureas) was significantly higher than people who did not take drugs (P<0.05). The multivariate Logistic regression analysis showed that there were regression relations between MAU and IGR population and HbA1c, systolic blood pressure; meanwhile, there were regression relations between MAU and T2DM population and fasting plasma glucose, diabetic course, systolic blood pressure, waist circumference.Conclusion The prevalence of MAU in1GR, DM among residents with middle-aged and elderly in Lanzhou Tieluxicun community was higher significantly. MAU was corrected closely with HbAlc, fasting plasma glucose, diabetic course, waist circumference, systolic blood pressure.