The Changes Of Serum Uric Acid, Neonatal Behavioral Neurological Assessment In Neonatal Hypoxic-ischemic Encephalopathy

Objective: to observe the changes of Serum uric acid（UA）, neonatal behavioralneurological assessment （NBNA）in neonatal hypoxic-ischemic encephalopathy anddiscuss its clinical significance.Methods: Analyze the serum UA and NBNA score of the29cases (10cases of mild,10cases of moderate, and9cases of severe) Neonatal hypoxic-ischemicencephalopathy in the acute phase and the16cases in the recovery withBECKMANCX9automatic biochemical analyzer, as contrast with the20cases ofnormal newborns.Results: Neonatal hypoxic-ischemic encephalopathy with mild, moderate and severedegrees of serum UA levels gradually increased, and there was very significantcontrast between the acute and the recovery phase（p<0.05）. Neonatalhypoxic-ischemic encephalopathy convalescent serum UA levels obviously decreased,compared with the normal control group, there was very significant contrast (p<0.05).The NBNA of neonatal hypoxic-ischemic encephalopathy group compared with thecontrol group was significantly lower. NBNA scores between the groups had verysignificant contrast（p<0.05）. The acute and recovery phase of HIE in serum UA andNBNA score was negatively correlated with each other.Conclusion: Serum UA and the NBNA and neonatal hypoxic-ischemicencephalopathy clinical classification are closely related. The more severe of Clinicalclassification, the higher of the serum UA; the lower of NBNA, as the diseaserecovers, the value of Serum UA gradually decreases. Serum UA and NBNA can be used as indicators of neonatal hypoxic-ischemic encephalopathy for early andpredicting prognosis.