Study Of The Relation Between Hs-CRP And Heart Rate Variability In CHD With Depression Neurosis

[Objective]To study the relation between the hypersensitive C reaction protein(hsCRP)value and heart rate variability(HRV)[Methods]According to the enrolling standard and removing standard, one hundred patients from the first Hospital of yangzhou from July2009to Feb.2011were divided into two groups:Group A (coronary heart disease patients) and Group B(patients with both coronary heart disease and depression). We collected the hsCRP value and HRVof the two groups,and calculate the significant differences of hs-CRP and HRV between the two groups,and the Relation between hs-CRP and Heart Rate Variability in Group B. All statistical tests were performed with two-sided alternatives and a type Ⅰ error of0.05and with the use of SPSS software(version17.0). All the measurement data was expressed as mean4±tandard deviation(mean±SD) andstudents t test was used to explore statistical significance. Chi-square test was used for analysis of categorical data.[Results]1.The hsCRP value was significantly higher in Group B than those in Group A(P<0.05). and the value of SDNN(Standard deviation of normal to normalintervals), RMSSD(Root meall square of standard deviation) andPNN50(Percentage NN interval deviation greater than50ms) was significantly lower in Group B than those in Group A(P<0.05).2.we analyze the Relation between hs-CRP and Heart Rate Variability in GroupB. We found that The hsCRP value and HRV were negatively relation in CHD with depression.The Correlation coefficient was SDNN(r=-0.635, P<0.05),MSSD (r=-0.800, P<0.05) and PNN50(r=-0.506, P<0.05).[Conclusions]The hsCRP value and HRV were negatively relation in CHD with depression.