Clinical Study On Modified Qingxin Lianzi Decoction Treating Type2Diabetes (Deficiency Of Both Qi And Yin Together With Dampness)

Objective:This subject studies the efficacy and safety of treatment of modified Qingxin Lianzi Decoction to type2diabetes (deficiency of both Qi and Yin together with dampness) randomly and contrastively, and the mechanism is also explored to provide the basis for application.Method:Systematically reviewing of the understanding of Chinese and Western medicine of type2diabetes, together with the tutor’s experience, we proposed that the deficiency of both Qi and Yin was the important pathological mechanism of the incidence of middle diabetes, which based on deficiency of both Qi and Yin together with dampness, and established the treatment of tonifying Qi and Yin and clearing away Heat-Dampness. We treated them with modified Qingxin Lianzi Yin. Selected74T2DM patients according to diagnostic criteria and divided them randomly to treatment group and control group with37in each group. The treatment group is treated with Qingxin Lianzi Decoction, Metformin hydrochloride tablets and the basic treatment, while control group only Metformin hydrochloride tablets After12weeks treatment, observed the change of parameters, such as the clinic symptoms, FPG、2hPG、HbA1c、BMI、TC、TG and so on. Then analyzed all the data with SPSS13.0statistical software.Results:(1) The improvement of clinical symptoms,such as dry mouth and throat, malaise and fatigue and so on, of treatment group was better than that of control group (P<0.05); to the clinical effect, in treatment group,5had excellent effect(14.3%),25had effect (68.6%),6had no effect (17.2%) and the whole rate of having effect was82.9%; in control group,1had excellent effect(3.1%),19had effect (59.4%),12had no effect (37.5%) and the whole rate of having effect was62.5%. So treatment group was better than that of control group(P<0.05);(2) After treatment, the FPG,2hPG and HbA1c were significantly lower than before(P<0.05); but treatment group were all better than the ones in control group (P<0.05); both of the two groups could reduce TC and TG, but after treatment TC has no significant difference between the groups(P>0.05); The treatment group was better than control group in inducing TG (P<0.05);(3) Patients’ BMI induced in both group after treatment (P<0.05) with no statistical significant between two groups (P>0.05);(4) There were1(2.7%) with intestinal adverse reactions in treatment group and3(8.1%) in control group without other side effects.Conclusions:(1) Modified Qingxin Lianzi Yin treatment of middle T2DM (deficiency of both Qi and Yin together with dampness) can improve not only on clinical symptoms and blood glucose, but also on lipid and weight;(2) Compared with control group, for treatment group has less gastrointestinal adverse reactions, patients adhere to the treatment better and of cause have good prospects for application.