Clinical Analysis Of The Treatment Process For72Infertile PCOS Patients

Objective：Analysis of the major causes of the infertile women withpolycystic ovary syndrome (PCOS), research and targeted analysis of itstherapeutic countermeasures, evaluate the effect of the ovulation andpregnancy.Methods: Collected72infertile PCOS patients treated in theReproductive Center of the First Hospital of Jilin Universitity fromDecember2009to October2012. All of the patients were received3cycles pre-treatement that involved control weight, correct their endocrineand metabolic disorder and so on according to their own condition beforeovulation induction. Then induced ovulation and monitored folliculardevelopmen, combined with urine LH test, the ovulation time would bepredicted. Finally, patients would take some procedures such as guideintercourse and AIH to help pregnancy. The statistical analysis used thegroup comparison methods.Results:1.The patients with overweight, disorder of endocrine and metabolicreceived pre-treatment such as loss weight, improve insulin sensitivityand reduce androgen level(χ2=17.647, p <0.001),2in72patients gotpregnant, but there was not statistical significance difference between twogroups.2.The PCOS follicular development analysis percentage:77%of allno development of folliculars, small follicles rupture occupied1.2%,7%showed unruptured follicle luteinized and14.8%restored ovulation. 3.Clomiphene ovulation cycle ovulation rate was84.55%, pregnancyrate was33.33%and no ovarian hyperstimulation syndrome and multiplefollicular development was observed.4.The ovulation rate of the clomiphene with hMG group was higherthan the clomiphene group (p=0.031), and the pregnancy rate was morehigher (p=0.015), the incidence of multiple follicular development andovarian hyperstimulation syndrome was higher in clomiphene with hMGgroup (p<0.05).5. The pregnancy rate of IUI is higher than the guidance intercoursegroup (χ2=17.647p <0.001).Conclusion:1. Some PCOS patients after pre-treatment could resume ovulationbefore ovulation induction, and also could increase the sensitivity toovulation drugs.2. The main cause that led to infertility in PCOS patients was thefollicular developmental disorder, ovulatory disorder accounts for lesspercentage. In other words, ovulation induction was the main work.3. Clomiphene has the higher ovulation rate and very low incidenceof multifollicular development and ovarian hyperstimulation, it was thefirst-line drug for ovulation induction.4.The ovulation rate and pregnancy rate was higher in theclomiphene with HMG group, but the risks of ovarian hyperstimulationsyndrome and multiple follicular development were significantlyincreased.5.The PCOS patients who has recovered normal ovulation afterovulation induction but still haven’t pregnant may have some immuneinfertility factors or other unexplained factors,such as sperm-egg bindingdisorder, which need to be further study. 6. AIH could further improve the pregnancy rate of infertile PCOSpatients.