Study On The Clinical And Biochemical Features Of 1348 Polycystic Ovary Syndrome(PCOS) Infertile Women

Objective : Polycystic Ovary Syndrome(PCOS) is the common endocrine cause of anovulatory infertility, a major factor for the metabolic syndrome. Expert conference held in Rotterdam in 2003 recommended ESHRE/ASRM as new diagnostic criteria for PCOS. While there are differences in clinical as well as laboratory characteristics of PCOS patients with different races. This study aims to investigate the clinical and biochemical features of Chinese infertile women with PCOS using clinical epidemiological investigation method, to evaluate the value of ESHRE/ASRM diagnostic criterion for Chinese PCOS patients, and to provide epidemiology basis for the diagnosis and etiology research of PCOS.Methods:Based on the ESHRE/ASRM diagnostic criterion, 1348 PCOS patients were enrolled into this study from March 2013 through August 2014 at the Four Hospital of Shijiazhuang. Meanwhile, 1143 infertile women without PCOS were selected as control. All subjects with identifiable endocrine disorders such as hyperprolactinemia, thyroid dysfunction, late-onset congenital adrenal hyperplasia, neoplastic androgen secretion were all excluded. The contents of questionnaire were made according to the ESHRE/ASRM diagnostic criteria. Data were analyzed by SPSS 13.0 for windows. A p-value less than 0.05 was considered statistically significant.Results:1 In this study, 65.2%(879/1348) PCOS patients were type III, which was different from the distribution of western countries(type I).2 94.1%(1268/1348) PCOS in this study aged at 20-35 years, which was in accordance with the age of reproduction.3 The starting time of oligo- or amenorrhea was different, 51.0%(687/1348) of them suffered at the beginning of menarche, and 49.0%(661/1348) once had regular menses, and then had secondary oligo- or amenorrhea for some reason.4 The proportion of the clinical as well as biochemical features of the PCOS patients were: hirsute: 18.0%(242/1348), the combination of overweight and obesity: 30%(404/1348), hyperandrogenism: 24.0%(324/1348), follicle number ≥12: 99.2%(1337/1348), ovarian volume ≥10ml: 98.6%(1329/1348), LH/FSH≥2: 24.1%(325/1348), IRT: 45.8%(368/1348).5 The length of menses, follicle number, blood sugar and insulin were significantly higher in obesity with PCOS.6 The length of menses, follicle number and hyperandrogenism were independently correlated with PCOS through Logistic regression analysis, which could be considered as independent indexes as the diagnosis of PCOS, but not ovarian volume ≥10ml The ORs were 17.37, 11.17 and 5.70 respectively.Conclusions:1 There were differences in clinical as well as laboratory characteristics of PCOS patients of different races.2 Compared with the western PCOS patients, Chinese patients with PCOS showed higher prevalence of menstrual irregularity, lower prevalence of hirsute, the combination of overweight and obesity and hyperandrogenism, and similar prevalence of PCO and insulin resist.3 Obesity leaded to severe menstrual irregularity and higher follicle number and heavey metabolic disorders.4 ESHRE/ASRM criteria was mainly suit for the PCOS patients in this study. Follicle number was more significantly than ovary volume both in etiology and diagnosis.