Role Of Clomiphene Citrate In Stimulating Ovulation In Polycystic Ovary Syndrome Patients

ObjectiveTo reevaluate the efficacy of induction of ovulation with CC in women with PCOS in the different timing of the menstrual cycle in a randomized controlled trial, discuss the timing of the administration to change its impact on ovulation rate and pregnancy rate.MethodA retrospective analysis from July 2013 to February 2014 in Linyi People's Hospital Reproductive Medicine clinic of 147 patients with polycystic ovary syndrome, a total of 230 cycles to five consecutive days of oral clomiphene citrate 50-150mg/d in the different timing of ovulation induction clinical data.After B super, FSH, LH, E2, P check to make sure, PCOS patients in the early follicular phase, according to the time of spontaneous bleeding after menstruation or withdrawal of the medicine is divided into A, B, C 3 groups. Group A:Spontaneous bleeding of menstruation or withdrawal herbal 2-9 days, a total of 74 cycles; Group B:Spontaneous bleeding of menstruation or withdrawal herbal 10-19 days, a total of 115 cycles; Group C:Spontaneous menstruation herbal withdrawal bleeding or the first 20-60 days, a total of 41 cycles. After be HCG ovulation after follicular maturation recommended life in B-monitored discovered observe the ovulation rate and pregnancy rate.Using SPSS 18.0 statistical software for statistical analysis of the data, count data were compared with chi-square test; multiple sets of measurement data first normality and homogeneity of variance test, normal distribution and homogeneity of variance to be one-way ANOVA analysis; significance level set at 0.05, that is considered when P<0.05, the difference was statistically significant.ResultsA group of ovulatory cycle number is 51, the number of ovulatory cycles is not 6, no advantage to 17 the number of follicles cycle, ovulation rate was 68%, the pregnancy rate was 20%; the number of ovulatory cycles in group B was 81, not the number of ovulatory cycles was 6, no advantage to 28 the number of follicles cycle, ovulation rate was 69.23%, the pregnancy rate was 24.79%; the number of ovulatory cycles in group C was 27, not the number of ovulatory cycles 2, no dominant follicle cycle number 12, the ovulation rate was 65.85%, the pregnancy rate was 14.63%. Grouped under different conditions in treatment time point, the sample index BMI, age, WHR index and the dosage was no significant difference (P> 0.05) in the mean performance and the degree of dispersion. Compare outcomes in different grouping samples, ovulation rate (P=0.94) and pregnancy (P=0.54) compared to the groups there was no significant difference. In this study, three groups of ovulation time (F=0.54, P=0.58), HCG endometrium thickness (F=2.99, P=0.06) and the dominant follicle count (F=0.17, P=0.92) were not significant differences.Conclusions1. clomiphene citrate PCOS patients with different timing of ovulation, ovulation rate, pregnancy rate is not statistically different.2. For clomiphene citrate ovulation induction regimen, progestin may withdraw the medicine must first be bleeding after ovulation induction treatment, reduce time to diagnosis and treatment of patients.