The Function Of Neurotrophic Action In Comprehensive Treatment Of Infectious Lower Extremity Lymphedema

Objective: To observe the function of Deproteinsed Calf Blood SerumInjection in the comprehensive treatment of infectious lower extremitylymphedema, in order to confirm the importance of neurotrophic action in thetreatment of infectious lower extremity lymphedema.Methods:120cases of the patients of unilaterally infectious lowerextremity lymphedema treated in our department from November2011toDecember2012, were randomly divided into the control group and thetreatment group. The patients of the control group was givenanti-inflammatory, improve circulation,comprehensive treatment such asphysical therapy, as appropriate, given the right amount of diuretics andurokinase therapy.The patients of treatment group was given DeproteinsedCalf Blood Serum Injection on the basis of the control group.The treatmentgroup plus the Deproteinsed Calf Blood Serum Injection treatments are amonth.Then recorded patella up and down15cm、ankle circumference of thetwo groups of patients before and after treatmentedge, respectively statisticstwo clinical cure rate, and the two groups of local skin tension blisters andulceration in patients given regularly dressing and record its wound healingtime，record and count the reducing rates of wound areas. Conclusion: The patients of the control group and the treatment groupbefore treatment weeks diameter was no significant difference (P>0.05); twogroups of patients before and after treatment limb circumference significantdifference (P <0.05), the difference of the control group and the treatmentgroup limb circumference after treatment was significant (P <0.05). The useof Deproteinsed Calf Blood Serum Injection based on comprehensivetreatment provides better results; clinical cure rate compared to the differencesof the two groups were significant (P <0.05), Deproteinsed Calf Blood SerumInjection in the treatment of infectious lower extremity lymphedema canincrease the treatment; wound healing time of local ulceration in the controlgroup and the treatment group had no significant difference (P>0.05), thereducing rate of wound area in the treatment group was significantly higherthan that in the control group on the every time point of treatment(P<0.05).Itmeans that using Deproteinsed Calf Blood Serum Injection can significantlyimprove the ability of patients with wound healing.The two groups of patientswith the symptoms,such as skin irritation, fever, pain, thick and tough, weresignificantly improved were discharged after treatment.Discussion: Deproteinsed Calf Blood Serum Injection may improvebrain blood circulation and nutrition disorders (ischemic injury, head injury)caused neurological deficit, have good nutritional role on peripheral nerve,clinical the use of more effective nutrition nerve drugs. Meanwhile, the drugperipheral arterial, venous circulation disorder caused by arterial disease, leg ulcers have a good therapeutic effect. Innervation of the lymphatic vessels isvery rich. This is the structural basis of nutrition neurological treatment oflower extremity lymphedema. The power of the lymphatic circulation mainlydue to the voluntary contraction of the lymphatic.The experiments confirmedthat the stimulation of adrenaline causes the contraction of lymphatic vessels.Therefore, the neurotrophic action of lymphatic peripheral nerve couldprompt independent contraction and the effective circulation of the lymph.The neurotrophic action eliminates vasospasm in the edema areas,in order tomake the lymph reflux. Lymphatic regeneration occurred in the lymphedema.The experiments show that VEGF-B, C play an important role in thedevelopment of lymphatic vessels process. The sympathetic nerve canstimulate VEGF-B, C to generate and release. Therefore, by the nutritionalrole of nerve, edema areas can increase the content of VEGF–B, C, promotelymphatic reproduction, to achieve the maintenance of the role of thelymphatic drainage.The drug used in the treatment of infectious lowerextremity lymphedema process,not only plays a role of nutritional nerve butalso improves circulation of accelerated edema. Thus it’s conformed that theimportance of the neurotrophic action of infectious lower extremitylymphedema.