The Clinical Observation Of "Buzhong Guizhi" Decoctum Treatment To Perimenopausal Women’s Knee Osteoarthritis

Objective:To test the clinical effects of Buzhong Guizhi decoctum which has the functions of tonifying Qi and blood and lustrating dampness and clearing away cold to treat perimenopausal women’s knee osteoarthritis that usually have deficiency of qi and blood and clod-dampness stasis syndrome.Methods:Using a randomized grouping and their own issues before and after the control study to equally divide82patients into treatment group and control group randomly. The treatment group was given modified Buzhong Guizhi decoctum (15g Chaihu,10g Zhishengma,30g Huangqi,20g Danggui,15g Baizhu,10g Chenpi,30g Dangshen,20g Guizhi,15g Hangshao,15g Duhuo,15g Huainiuxi, lOg Haitongpi,10g Haifengteng,15g Yinyanghuo,15g Yiyiren, lOg Changpu, lOg Dazao, lOg Zhigancao,15g ShengJiang), which was extracted3times and200mL each time, namely every milliliter contains0.48g primary explosive. It was taken about half an hour after meal,3times a day, and200mL each time. The control group was given Gubi mixture (made by TCM Preparation Room of Yunnan Provincial Hospital of TCM) and it was taken in the same way. Half an hour after taking the herbal decoctum, both the treatment group and the control group were given Glucosamine sulfate potassium capsule,3times a day,2pills each time, one course of treatment was one month by two groups. Compared the final treatment effects, clinical symptoms and signs (including the changing of joint function and the syndrome of Chinese traditional medicine), as well as X-ray etc. indicators of two groups,at the same time, consulted "Chinese herbal medicine new medicine clinical research principles" made the evaluation of the clinical therapeutic effect. Results:We planed to investigate60cases, actually investigated82cases, which included41cases of treatment group and41cases of control group. Among the investigation,2cases did not complete the treatment,1case did not conform to the treatment (see Table1).82cases of all analysis collected works,79cases were fit for protocol set, and80cases were security data set. In fact, there were only40cases of the treatment group and39cases of the control group. Compared the effective rate of two groups, the difference has statistically significant (p<0.05), and compared clinical control efficiency with obvious efficiency, the difference has also statistically significant (p<0.05). The patients of the two groups were significantly improved in clinical symptoms, signs, syndromes (p<0.05), and their relative marks decreased significantly, the improvement of the main projects and the main integral degree of the treatment group were better than those of the control group. The knee X-ray of the two groups did not show any difference within one month. During the observation period, two groups’ tests of blood routine, urine routine, excrement routine, liver function, kidney function, erythrocyte sedimentation rate (ESR), C response protein, and electrocardiogram were not discovered serious exception or adverse reaction.Conclusion:Buzhong Guizhi decoctum has efficient to treat and improve perimenopausal women’s knee osteoarthritis that usually have deficiency of qi and blood and clod-dampness stasis syndrome, and obviously improve clinical symptoms(that include joint function, symptom of TCM). It has no obvious side effects, and can be used as a clinical treatment for osteoarthritis.