The Clinical Observation Of Buzhong Guizhi Decoction In The Treatment Of Ankylosing Spondylitis Wind-dampness Syndrome

Objective: To test the clinical effects of Buzhong Guizhi decoctum which has thefunctions of tonifying Qi and blood and lustrating dampness and clearing away coldto treat ankylosing spondylitis wind-dampness syndrome that usually havedeficiency of qi and blood and clod-dampness stasis syndrome.Methods: Using a randomized grouping and their own issues before and after thecontrol study to equally divide73patients into treatment group and control grouprandomly. The treatment group was given modified Buzhong Guizhi decoctum (15gChaihu,10g Zhishengma,30g Huangqi,20g Danggui,15g Baizhu,10g Chenpi，30gDangshen,20g Guizhi，15g Hangshao,15g Duhuo，15g Huainiuxi,10g Haitongpi,10g Haifengteng,15g Yinyanghuo,15g Yiyiren,10g Changpu,10g Dazao,10gZhigancao,10g ShengJiang), which was extracted3times and200mL each time,namely every milliliter contains0.51g primary explosive. It was taken about half anhour after meal,3times a day, and200mL each time. The control group was givenGubi mixture (made by TCM Preparation Room of Yunnan Provincial Hospital ofTCM) and it was taken in the same way. Half an hour after taking the herbaldecoctum, both the treatment group and the control group were given sulfasalazine,3times a day,4pills each time，one course of treatment was one month by twogroups. Compared the final treatment effects, clinical symptoms and signs (includingthe changing of joint function and the syndrome of Chinese traditional medicine), as well as X-ray etc. indicators of two groups,at the same time, consulted “Chineseherbal medicine new medicine clinical research principles” made the evaluation ofthe clinical therapeutic effect.Results: We planed to investigate60cases, actually investigated73cases, whichincluded37cases of treatment group and36cases of control group. Among theinvestigation,2cases did not complete the treatment,1case did not conform to thetreatment (see Table1).73cases of all analysis collected works,70cases were fit forprotocol set, and80cases were security data set. In fact, there were only35cases ofthe treatment group and35cases of the control group. Compared the effective rate oftwo groups, the difference has statistically significant (p<0.05), and comparedclinical control efficiency with obvious efficiency, the difference has also statisticallysignificant (p<0.05). The patients of the two groups were significantly improved inclinical symptoms, signs, syndromes (p<0.05), and their relative marks decreasedsignificantly, the improvement of the main projects and the main integral degree ofthe treatment group were better than those of the control group. The articulationessacroiliaca X-ray of the two groups did not show any difference within one month.During the observation period, two groups’ tests of blood routine, liver function,kidney function, erythrocyte sedimentation rate (ESR), C response protein, andelectrocardiogram were not discovered serious exception or adverse reaction.Conclusion: Buzhong Guizhi decoctum has efficient to treat and improveankylosing spondylitis wind-dampness syndrome that usually have deficiency of qiand blood and clod-dampness stasis syndrome, and obviously improve clinicalsymptoms(that include joint function, symptom of TCM). It has no obvious sideeffects, and can be used as a clinical treatment for osteoarthritis.