The Development Of Ciclopirox Olamine Cream For Gynecological Use

According to the survey,75%emen suffers fungal vaginitis at least once in their lifetime, the incidence of which is so high among female friends. The fungal vaginitis is a kind of vaginal inflammatory lesions,which mainly caused by candida albicans. This bacteria lives in even Normal vaginal, when the local environment of organism becomes abnormal, it is easy to occur Inflammation.it’s Common in pregnant women、young girls、 diabetic patients、vitamin B deficiency、immunocopromised persons、and people who receivied a large number of estrogen therapy and antibiotic.Fungal vaginitis is a common gynecological infections, Because of its discom-fort as unique itching, burning etc, which brought much suffering to the patients. what’s more, fungal vaginitis always relapses. During the process of repeate d treatment, it gradually develops resistance to some therapeut ic drugs. Even associated with other bacterial infections, which urgently need the emergence of wider antibacterial range and stronger bactericial capacity drugs. Research found that the treatment of fungal vaginal inflammation can use a new type of broad-spectrum antifungal——ciclopirox olamine cream for the cure. Ciclopirox olamine,also known as ciclopirox division, ciclopirox ethanolamine division, belongs to the derivative of pyridine ketones, is a new type of artificial synthetic drugs,which has the following features:a very strong penetration to the stratum corneum of skin fungaus’survival, therefore, it has significant inhibitory bactericidal effect on the shallow and deep fungal of cuticle like body surface, mucous membranes, nail bed and so on. In addition to inhibiting the growth of Gram-positive bacteria same as imidazole(commonly used drugs for various dermatophytes and bacterial infections),also have some inhibitory effect on Gram-negative bacteria; it can inhibit the growth of Candida albicans well in low concent ration (1%), and mycoplasma, trichomonas vaginalis, pseudomo nas aeruginosa in higher concentration.Candada vaginitis is infection in vitro, most use for local delivery. Currently, the formulations listed in domestic is mainly vaginal suppository, which releases slowly, inconvenient to use, and can not be promptly withdraw when adverse reactions happen, therefore, this article made it into vaginal cream, greatly improved the release rate and usage control.And this gynecological formulation has no market promotion in the domestic, it would have a certain significance on studying.