Times New Roman The Study On The Antifungal Activity Of The Three Antifungal Agents To The Trichophyton Rub Rum

Objective:To investigate the in vitro antifungal activity about Miconazole Nitrate Cream,Terbinafine Hydrochloride Cream and Amorolfine Hydrochloride Cream and the drug resistance of the Trichophyton rubrum for them.Methods:Choosing sixteen strains of Trichophyton rubrum,including fifteen isolates of pathogenic fungus and one strains of standard strains.Using agar diffusion method to record the diameter of the inhibition zone around the well full of each cream,and compare them with the standard fungus and the isolates of pathogenic from clinical.Results:1.Both of three drug have formed inhibition zone,and the inhibition zone of Amorolfine Hydrochloride Cream is bigger than Terbinafine Hydrochloride Cream,and both of them are stronger than Miconazole Nitrate Cream(P<0.01),ie,They all have significant difference in statistical.There are no obvious difference in inhibition zone between the pathogenic fungus isolated from patients and standard strains Under the condition of external used drug intervention(P>0.05).Conclusion:The antifungal activity of Amorolfine Hydrochloride Cream is stronger than Terbinafine Hydrochloride Cream,and they are both stronger than Miconazole Nitrate Cream.2.The three drugs has yet to produce drug resistance or drug resistance is not strong.