Relationship Between Blood Pressure Parameters And Outcome After Stroke

Background and Objective：Ischaemic Stroke, as a leading cause ofmorbidity, mortality and disability rate, has become a serious threat to thehealth of middle-aged and elderly people.There are so many factors thatinfluence the functional recovery in patients,especially the blood pressure.This study explores the possible relationship between BP parameters andoutcome following stroke.Methods:Patients were chosen by adoption standards in NeurologyDepartment of our hospital from May2011to December2011.The clinicaldata,baseline blood pressure and24-hour ambulatory blood pressuremonitorin(ABPM) of these patients were collected. Barthel Index (BI)wasused to assess the clinical outcome at7day after stroke. Modified RankinScale(mRS）was uesd to assess the stroke outcome at28and90day. Theseinfluencing factors compared in groups. Logistic regression analyses werecalculated for stroke outcome associated with these factors.Results: Analyses include84patients with acute ischemicstroke.Baseline characteristics are as follows: mean age,71.6years;45.2%males;mean hours admitted hospital16.3; mean baseline NIHSS6.7, Themain Blood Pressure Circadian Rhythm(BPCR)types are non-dipper andreversedipper, just4cases are dipper type. Univariate Analysis results:Smoke history,hypertension history,storke history, Average PulsePressure(APP),Average Pulse Pressure Index(APPI), Diastolic BloodPressure Variability(DBPV),Mean Arterial Pressure Variability(MAPV) aredifferent in each comparing groups. Average Systolic Blood Pressure(ASBP)is related to7day prognosis. Blood Pressure CircadianRhythm(BPCR)is just different in90day comparing group. Logisticregression analyses show that Systolic Blood Pressure Variability(SBPV),BPCR are significantly associated with ischimic stroke outcome in early andmiddle term.MAPV is only related to7day stroke outcome.Conclusions: SBPV and BPCR are the influencing factors of strokeoutcome in early and middle term. MAPV is only related to early strokeoutcome.APP and APPI can be the influencing factors in short time andmiddle time prognosis. However, neither of these findings remainedsignificant after adjustment for the age,sex, previous history and so on.