The Correlation Between Blood Pressure Variability In The Acute Stage And Outcome Of Ischemic Stroke

【Objective】To investigate the correlation between blood pressure variability and functional outcome of the acute phase of ischemic stroke.【Methods】144 inpatients diagnosed as ischemic stroke in the neurology of the first hospital affiliated to Fujian medical university were recruited into this study.Collected the inpatients’ information(such as admission number,telephone number,age,gender,time from onset,NIHSS on admission,history of hypertension,history of diabetes,history of atrail fibrillation,information about drugs using at the time of hospitalization and so on),blood pressure measurements and m RS on days 15 of their illness,and then complete the m RS on days 30 and 90 of their illness in the form of outpatient follow-up or telephone follow-up.Worked out the standard deviation and coefficient of variability what are the parameters of the blood pressure variability.Divided all inpatients into two groups(good outcome and poor outcome)according to m RS,and then compared the blood pressure variability between the two groups;divided all inpatients into two groups(small blood pressure variability and large blood pressure variability)according to the value of the parameters of BPV,and then compared the functional outcome between the two groups;painted the trend chart between the blood pressure variability and the rate of poor outcome,and then analyzed the tendency;analyzed the relationship between blood pressure variability and true value of blood pressure(blood pressure on admission and mean blood pressure),antihypertensive drugs.Adopted t-test,χ2 –test and logistic regression to analyze the date.【Results】(1)Single-factor analysis: it exists statistical significance on blood pressure on admission,NIHSS on admission,BP-SD,SBP-CV and whether using dehydrating agents between the two different outcome groups on days 15 of their illness;it exists statistical significance on blood pressure on admission,NIHSS on admission,BP-SD,SBP-CV and whether using dehydrating agents,age between the two different outcome groups on days 30 of their illness;it exists statistical significance on NIHSS on admission and whether using dehydrating agents between the two different outcome groups on days 90 of their illness.Multiple-factor analysis:NIHSS on admission was independent prognostic factor,and blood pressure on admission and age were independent prognostic factors on days 30 of their illness.(2)There was no statistical significance on functional outcome between the two different BPV groups,but the m RS score in the group with small BPV was lower than the one with large BPV,and the percentage of inpatients with good outcome in the group with small BPV was also bigger than the one with large BPV.(3)Along with the increase of SBP-SD、SBP-CV and DBP-SD,the percentage of patients with poor outcome on days 15 and 30 of their illness was bigger.And there was no the same change tendency between BPV and the percentage of patients with poor outcome on days 90 of their illness.(4)Blood pressure on admission especially the SBP was significantly related with blood pressure variability and the higher the SBP,the bigger the SBP-BPV.There was statistical significance on blood pressure variability between the group of taking antihypertensive drugs and the group of no taking before the drug intervention,and there was no statistical significance after he drug intervention.【Conclusion】SBP-BPV was the early prognostic factor,and the better the early outcome,the smaller the BPV.The percentage of patients with poor early outcome becomes bigger along with the increase of SBP-BPV and DBP-SD.The lager the blood pressure on admission and mean blood pressure,the bigger the blood pressure variability,blood pressure on admission but not mean blood pressure was significantly related to the blood pressure variability,and antihypertensive drug may reduce the blood pressure variability.