Relationship Between Blood Pressure Indices Determined By Blood Pressure Measurement And Types Of Blood Pressure And Stroke In Anqing And Surrounding Areas

Objective To examine the relationships between BP index and stroke, and the relationship between types of blood pressure and strok.Methods From1995until2005, several studies were research in districts of Anqing City and its surrounding areas.58530Participants who took part in the baseline survey were contacted with in-home interviews, registered and confirmed of stroke information.In this study,21533participants were evaluated. During an average follow-up of9.49years among survivors,504strokes occurred. Associations between stroke and each BP index were determined using Cox proportional hazards regression.Results After the exclusion of participants that we didn’t get stroke information and participants who had happened stroke at baseline and participants that aged35years or younger at baseline,some participants with missing some values at baseline(age,sex, SBP,DBP), complete data were obtained in26608patients. During an average follow-up of9.49years among survivors,504strokes occurred. A10mm Hg higher SBP was associated with approximately a43%higher risk of total stroke (HR=1.43,95%CI:1.39～1.47) and also a36%higher risk of ischemic stroke (HR=1.36,95%CI:1.28～1.44) and a45%higher risk of hemorrhagic stroke (HR=1.45,95%CI:1.38～1.53). A5mm Hg higher DBP was associated with approximately a39%higher risk of total stroke (HR=1.39,95%CI:1.34～1.44) and also a32%higher risk of ischemic stroke (HR=1.32,95%CI:1.22～1.42) and a40%higher risk of hemorrhagic stroke (HR=1.40,95%CL1.32～1.49). A5mm Hg higher MAP was associated with approximately a34%higher risk of total stroke (HR=1.34,95%CI:1.31～1.37) and also a27%higher risk of ischemic stroke (HR=1.27,95%CI:1.21～1.34) and a35%higher risk of hemorrhagic stroke(RR=1.35,95%CI:1.29～1.41). A10mm Hg higher MAP was associated with approximately a43%higher risk of total stroke (HR=1.43,95%CI:1.37～1.50) and also a37%higher risk of ischemic stroke (HR=1.37,95%CI:1.24～1.50) and a33%higher risk of hemorrhagic stroke(HR=1.33,95%CI:1.27～1.52). SDH was a stronger risk factor to stroke than ISH(HR=2.43,95%CI:1.93～3.06).SDH was a stronger risk factor to Ischemic stroke than ISH(HR=1.82,95%CI:0.8204.04).SDH was a stronger risk factor to hemorrhagic stroke than ISH(HR=2.40,95%CI:1.47-3.90).SDH was a stronger risk factor to stroke than ISH(HR=5.85,95%CI:1.61-2.94) in men.SDH was a stronger risk factor to hemorrhagic stroke than ISH(HR=3.26,95%CI:1.65-7.25) in men.SDH was a stronger risk factor to Ischemic stroke than ISH(HR=3.81,95%CI:1.98-7.34) in men.Conclusion All baseline BP indices were significantly higher in subjects who developed stroke than in those who did not,both men and women. A10mm Hg higher SBP,a5mm Hg higher DBP,a5mm Hg higher MAP, a10mm Hg higher PP were associated with higher risk of stroke.We obtained similar results when we restricted analyses to participants in several age groups (35-55years,>55).The strength of the associations was different for ischemic and hemorrhagic and attenuated with age. The analyses demonstrated that a given reduction in SBP plays a more significant role in the decrease of hemorrhagic stroke incidence. Maybe a potentially weaker relative association for older age groups(>60years), however,the higher overall stroke rate in this group means that in absolute terms, the benefits of a given reduction in SBP are likely to be greater. SDH was the highest risk to stroke, especially in men.