The Relationship With Severity Of Acne And Other Factors And Clinic Observation After Therapy With Finasteride

BACKGROUNDAcne is a chronic inflammatory disease of the pilosebaceous follicle, theincidence of acne is70to87percent. Genetic factors, unhealthy lifestyles,stress from social life and overuse of cosmetics have made severe acnemuch more incidence in recent years, approximately8to18percent.Acne can cause a series of clinical symptoms, such as comedones,papules, pustules, nodules, cysts and various degrees of scarring. Thepathogenesis is complex, absolutely or relatively increased androgenactivity and excessive secretion in the sebaceous glands, abnormalhyperkeratosis in the pilosebaceous duct, microbial infections andproduction of inflammatory mediators in pilosebaceous follicle are allplay the important roles in it. Perceived as a teenage disease, acne oftenpersists into adulthood. the first attack of acne occured late or taken longcourse beyond the age of25years, is known as post-adolescent acne orlate-onset acne, it occurrs most commonly in women, and the incidence issignificantly decease beyond the age of45years.Acne has been demonstrated to be a hereditary disease and is prone topolygenic inheritance. Increased androgen activity and excessivesecretion, seborrhea, abnormal hyperkeratosis in the pilosebaceous duct,immune inflammatory reaction, known as the pathogenesis of acne, havea lot to do with genetic factors. Recent research indicates that gene determines the severity of acne to some extent.Contraceptive drugs, career exposure, cosmetics, smoking and unhealthydiet were considered to be associated with acne. Previous studiesgradually notice that high GI loads in diet perhaps throughhyperinsulinaemia leading to increased androgens, increased IGF-1, andaltered retinoid signalling.OBJECTIVEInformation of166cases of acne patients, including age, gender, familyhistory, BMI was retrospectively evaluated to determine whether they hada lot to do with each other. The present study aims at theoretical basis forfuther treatment and prevention.PATIENTS AND METHODS166patients were enrolled between their visiting time at May.2010andSept.2011. Put down the records of gender, age, family history, BMI, theGAGS used to evaluate the acne and severity. Analyze the relationshipbetween severity and above factors. SPSS13.0software applications ofthe data will be used for statistical analysis. P<0.05believe that theresults were statistically significant.RESULTS1. Basic information: All the cases, ageing from11to59(average25.19±8.07y) have140females (84.34%) vs26males (15.66%).162with a history of acne (97.59%) and4without a history of acne (2.41%). The proportion of patients suffered mild acne increase asthey grow. Patients with moderate acne are concentrate in years from16to25.2. The relationship of severity and factors, it has significant difference inthe group of BMI18.5~23.9(P<0.05), in both gender group, theseverity of acne is focused on the moderate(P<0.05), compared withthe mild and moderate group, the severe acne has the most familyhistory(P<0.05).3. In the mild group, skin scores have no difference between beforetherapy and after8weeks therapy(P>0.05), but the difference betweenbefore therapy and after4or12weeks therapy in mild group andanother two groups before and after therapy are significant(P<0.05).The improvemet rates of all group are47.2%、62.9%、64.0%and therecurrence rate of all group are16.7%、15.2%、4.0%, both have no significantdifference(P<0.05).CONCLUSION1. The average first onset age of acne patients is17-year in males and20-year in females. Acne is tend to concentrate in mild kind as they grow.There’s no significant difference between family history and severity.This is what different from the records on literature.2. The standard of the biggest group divided with the foundation ofhistory or gender tends to normal. The inluence of BMI on the severity ofacne is tiny. 3. Finasteride is effect as the therapy for acne，particular for the severeacne.