Research On The Quality Of Life And TCM Syndrome Of Chronic Hepatitis C

Objective:To identify the chinese medicine symptom and syndrome distribution character、quality of life(QOL) character and the relationship between them, which is good for the treatment of chronic hepatitis C in providing a scientific basis.Methods:All120patients Diagnosed as chronic hepatitis C are from the clinic service and ward of Jiang Su Province Hospital of TCM, People’s Hospital of Jiang Su Province, and the second hospital of Nanjing infection department on April2009-Jully2011.Clinical data are collected to creat databases including breaf medical history, symptoms, syndrome types, laboratory tests(such as liver function, HCV-RNA quantative, B ultrasonic-3), SF-36scores and so on.Infection routes, symptoms, characteristics of the Chinese medicine types of patients and QOL with CHC are analyzed by using SPSS16.0statistical software, while the correlation between Chinese medicine types and QOL and correlative fators will be researched after that.Results:1.The ways of HCV infection diverse. Blood and blood products transfusion accounts for75%, which prompted that blood and blood products transfusion remains the most important means of infecting HCV.The number of drug addicts infected HCV, accounting for8.3%, represents the second place in this survey, which indicates that the number of HCV infecion by drug abuse is still rising.2.In this survey it is collected82symptoms in all in CHC patients, symptoms of high frequency is fatigue(69.2%), flank pain(68.3%), dark urine(51.7%), irritability(47.5%), back and leg weakness(37.5%), have a deep sigh(36.7%), dark complexion(35.0%), dry mouth(35.0%), thirsty(31.7%), dizzy(31.7%), abdominal distension(31.7%), bitter taste of mouth(29.2%).Disnormal motional reaction symptoms shows high frequency of occurrence.The majority color of the tongue is red, and violet red、dark red、pricking needling or ecchymosis are usually seen, the color of the tongue coating shows white and greasy mostly, and the body of the tongue often becomes big fat or with teeth prints.3.In this suvey of120CHC patients, stagnation of liver-QI with deficiency of the spleen type posseses32.5%, the type of damp-heat in liver and cholecyst accounts for30.8%, blood stasis possesses12.5%, type of deficiency of the Liver-yin and Kidney-yin accounts for19.2%, and deficiency of Spleen-yang and Kidney-yang type accounts for5%.The primary cause of excess type dues to accumulation of damp-heat in the liver and cholecyst, while deficiency type is made up with deficiency of the Liver-yin and Kidney-yin type in the majority.4.QOL of CHC patients have certain correlation with gender、age、culture degree、insurance and course of disease.5.QOL has no correlation with ALT、AST、TBIL and HCV-RNA;each domain’s score differ between light、middle and severe Ultrasonic B injury, while score of light group>middle group>severe group.6.The QOL score of each domain in type of stagnation of liver-QI with deficiency of the spleen and the type of damp-heat in liver and cholecyst is higher than the other three types, while type of blood stasis has lower score in each domain;score of each domain has a negative correlation with accumulated points of syndrome.7. Each domain’s score of QOL get higher when the patient get sustained response after antiviral treatment.Conclusions:1.Blood and blood products transfusion remains the most important means of infecting HCV at current, while drug abuse transfusion is rising.2.CHC is a long course disease, and its symptoms are more complicated than thought before.The symptoms of both type damp-heat in liver and cholecyst and the stagnation of liver-QI with deficiency of the spleen type are more common, while less common symptoms are found in type of deficiency Spleen-yang and Kidney-yang. The character of the tongue:red tongue, white and greasy tongue coating, dry tongue and coating, big fat or teeth prints tongue body, and violet red、dark red、pricking needling or ecchymosis is usually seen.3.The primary cause of excess type in CHC patients dues to accumulation of damp-heat in liver and cholecyst, while deficiency type is made up with deficiency of the Liver-yang and.Kidney-yin type in the majority.4.QOL of CHC patients is affected by general data such as gender、age、culture degree、 insurance and course of disease.5.QOL has no correlation with ALT、AST、TBIL and HCV-RNA;QOL is better when the damage of liver ultrasonic B is slighter.6.Different TCM syndrome type has different QOL.QOL of type of stagnation of liver-QI with deficiency of the spleen and the type of damp-heat in liver and cholecyst is higher than the other three types.