The Variation And Relevance Of Adiponectin And Resistin Level Of Diabetic Women Inpregnancy

Objective:to research the variation and relevance of adiponectin (APN) and resistin level of normal or diabetic women in pregnancy in their first, second and third trimester.Methods:Regular checking patients of our hospital starting from the early pregnancy were selected, who were without hypertension, diabetes or endocrine diseases and pregnant naturally. Phlebo-blood was drawn and the serum was detached and frozen under-80℃at the first trimester, and the blood pressure as well as body weight were measured concurrently. Glucose challenge test(GCT) were conducted during their24th-28th week of pregnancy. If the result was≥7.8mmol/L, examinations of oral glucose tolerance test (OGTT) and the level of fasting insulin will be conducted three days later,3ml serum drawn and kept under-80℃meanwhile. The GDM was diagnosed according to the7th OB-GYN edited by Le Jie that the patient is tested under the condition of fasting/1/2/3h, while the blood glucose correspondingly being5.6/10.3/8.6/6.7mmol/L. GDM can be confirmed under the circumstance that the patient reaches (or exceeds) two, three or four indicators of the standard. If four of the are normal, it is called normal glucose tolerance (NGT). Consecutively kept following the patients through the gestation, and the serum was detached and frozen under-80℃at delivery. The samples of the serum were tested by ELISA afterwards, the data of which would be statistical analyzed.Results:sample size:33for NGT,44for GDM.1.The concentration of APN of each group was compared. The divergence between the three periods of the two groups were of statistical significance (P<0.05). The level of APN concentration for NGT group was lower than the NGT group compared between the same periods.2.The concentration of resistin of each group was compared. The divergence between the three periods of the two groups were of statistical significance (P<0.05). The level of APN concentration for NGT group was higher than the NGT group compared between the same periods.3.Univariate analysis:APN:early/later period (positive correlation); middle/third trimester (positive correlation). Resistin:first/third trimester (positive correlation); second/later period (positive correlation). The correlations were of statistical significance.4.Bivariate analysis:negative correlation between APN and resistin, among which the relevance of:the level of APN in the first trimester and the resistin in the third trimester/the level of APN and resistin in the third trimester were of statistical significance.5.Stepwise multiple regression analysis: it suggested that the level of APN was defined dependent variable, BMI/fasting blood glucose/fasting blood insulin/IR/reisistin in first trimester independent variables, and fasting blood insulin/IR became the influencing factor of APN r2=0.118. the level of APN was defined dependent variable, fasting blood glucose/fasting blood insulin/IR became the influencing factor of resistin. r2=0.175Conclusions:1.the level of APN is in the downward trend as process of pregnancy, while the resistin in the upward.2.The level of APN of GDM patients is averagely lower than the normal patients in each period, while the resistin level is higher.3.The APN level in first trimester is higher than that in third trimester. The divergence is of statistical significance, and as a result the APN level can be regarded as a criterion predictor for GDM for an advanced treatment. The level of APN is on the rise in the third trimester of pregnancy in significant comparison to that in first trimester.5.The levels of APN and resistin are in negative correlation, which is of vital importance for the screening、prediction and estimation of prognosis of GDM, providing new theoretical foundations for the diagnosis and treatment of the GDM.