Clinical Study On The Treatment With Tongfu Mixture For The Acute Phase Of Phlegm-heat And Bowel-repletion Type Of Hypertensive Intracerebral Hemorrhage

Objective:Through the observation of the clinical efficacy, safety, and practicality of Tongfu mixture in treating the phlegm-heat and bowel-repletion type of hypertensive intracerebral hemorrhage (HICH), and through the observation of the advantages of shortening hospital stays and saving medical costs, provide a scientific basis for the Tongfu mixture’s treat of phlegm-heat and bowel-repletion type of HICH during the acute phase of clinical application.Methods:Select110cases of patients that are diagnosed of phlegm-heat and bowel-repletion type of HICH in our hospital. Divide them into the group of Tongfu mixture plus general treatment (named groupl hereinafter) and the group of general treatment (named group2hereinafter), which are respectively of60cases and50cases. The groupl took30ml of the Tongfu mixtureorally, three times per day. The group2was given general treatment. The patients of the two groups were evaluated by their NIHSS score, TCM syndrome score, the absorption situation of hematoma, and the effects on liver and kidney functions respectively before treatment and two weeks after treatment.. We also analyzed and evaluated the time of hospitalization, and hospital costs.Observation indications and methods:Observe the clinical efficacy, the NIHSS score, TCM syndrome score, the absorption situation of hematoma, the effects on liver and kidney functions, the time and costs of hospitalization of the two groups. Take reference to the standards of the indications for grading quantitative assessment, and fill the clinical observation sheet.Statistical analysis:The measuring datas were analyzed by t-test, counting datas analyzed by X2test, and grading information analysed by Ridit.Results:1. Analysis of clinical efficacyAs for Tongfu mixture treatment of phlegm-heat and bowel-repletion type of HICH patients, the groupl has20cases recovered,17cases of significant progress,12cases of progress,8cases of little progress,3cases unchanged, and0cases of deterioration. The total efficacy is of95%. As for the group2, there are11cases recovered,12cases of significant progress,13cases of progress,5cases of little progress,8cases unchanged, and1case of deterioration. The total efficacy is of82%. The efficacies of the two groups are statistically significant (P <0.05). the groupl has a better clinical efficacy than the group2.2. Comparison of NIHSS scores of the two groupsThe NIHSS scores of the groupl before and after treatment are significantly different. The NIHSS scores of the group2are also obviously different. But inter-group comparison analysis of the NIHSS scores between the groupl and the group2shows that, both the two groups can lead to a significant improvement on the NIHSS scores. However, the groupl is better.3. Effects on TCM syndromesBoth the groupl and the group2before and after treatment have a significant difference on TCM climate score. It is showed by comparison between the two groups that, both the two groups could significantly improve the TCM syndromes, but the groupl has a better result.4. Effects on the absorption of hematomaBefore treatment, the hematoma sizes of the two groups of patientshave no statistical significance. By comparison before and after treatment, both the two groups have an obvious difference; The inter-comparison shows that the groupl has a better result.5. Effects on liver and kidney functionsThe effects on liver and kidney functions of the two groups before and after treatment, have no significant difference, P>0.05. After treatment, the inner and inter comparison of statistical tests between the two groups have nostatistical significance, which suggests that neither the two groups havesignificant effects on liver and kidney functions.6. Effects on time and costs of hospitalizationThe comparison between time and costs of hospitalization of two groups of patients, P<0.05, suggests that the groupl is better than group2in the aspects of shortening hospitalization time and costs. Conclusion: The patients who received Tongfu mixture treatment of phlegm-heat and bowel-repletion type of HICH, can significantly improve the clinical symptoms, the NIHSS score, TCM syndrome score, hematoma absorption. The course and medical costs of treatment can be reduced, and the neurological rehabilitation and qual ity of life can be improved. It is suggested that the Tongfu mixture treatment of phlegm-heat and bowel-repletion type of HICH has a better effect, and provides a new path for thel treatment of phlegm-heat and bowel-repletion type of HICH.