| Objective:Through the endometriosis conservative postoperative patients were randomized to take series of Chinese medicine, such as guifuyin, danchiyin, or qidanyin and gonadotropins agonists (GnRH-a) drugs or gestrinone, to evaluate the relapse rate, pregnancy rate of the two interventions within2year after conservative surgery, And discussing the recurrence related factors and the feasibility of preventing the recurrence after conservative surgery with Chinese medicine diagnosis and treatment in order to seeking for the best formulaes that are efficacy, stability, low recurrence rate and adverse reaction.Methods:This study belong to the state eleventh five-year plan support plan subject "Chinese medicine therapy and pelvic uterus the clinical research and curative effect evaluation"(topic Numbers:2006BAI04A17) part of the content, and the center, prospectie, randomized, controlled clinical research methods. Collect in April2008to February2010the independent group of240cases of first open or laparoscopic surgery conservative pathologically after pelvic cavity of endometriosis patients with complete clinical material, divided into research group and control group, the120cases. According to r-AFS score, the treatment of three month or six months. The observation group according to TCM syndrome differentiation points respectively take guangxi attached type drink, Dan red drinks, Qi Dan drink series formulas, the control group gonadotropins agonists (GnRH-a) drugs or pregnant three ketene. Both groups in medication during and after discontinuation of every three menstrual cycles (menstruation is not law or the amenorrhoea every3months) patients were followed up for one time, all patients were followed up for time is2years. Follow-up period compared with two groups of patients, pregnancy and recurrent, follow-up period if patients pregnancy or recurrence judgment, the research suspended. April2008to February2010patients by the researchers completed the specific situation.Results:This study takes203cases as research objects who complete treatment duration and were followed up to2year, and the observation group is105cases and control is98cases among them.2year recurrence rate of two groups after conservative surgery was not statistically significant difference (P>0.05); Two groups of EMs patients after two years of conservative recurrence rate there were no statistically significant difference (P>0.05);The observation group40patients with high frequency recurrence rate, the control group25to29patients with high recurrence; The observation group in June after recurrence rate is high, the control group in September after recurrence rate high; The observation group do laparoscopic surgery and open surgery the recurrence rate is no significant difference (P>0.05); The observation group Ⅰ, Ⅱ period and Ⅲ, Ⅳ period recurrence rate is no significant difference (P>0.05), and the control group Ⅰ, Ⅱ period and Ⅲ, Ⅳ period is the recurrence rate significant difference (P<0.05); Two groups of laparoscopic surgery and open surgery recurrence rate is no statistically significant difference (P>0.05); Two groups of I, II period and III, IV issue of the recurrence rate is no statistically significant difference (P>0.05); The observation group with the capsule opportunely preoperative recurrence rate compared with no significant difference (P>0.05); The observation group with the period before the recurrence rate compared with no significant difference (P>0.05).Two groups of EMs patients after two years of conservative pregnancy rates there were no statistically significant difference (P>0.05); The observation group and control group pregnancies were25to29are in the majority, followed by30-34years old,40years later did not find pregnancies; The observation group after3months in pregnancy rate is high, the control group in June after pregnancy rate; The observation group do laparoscopic surgery and open surgery pregnancy rate there were no statistically significant difference (P>0.05); The observation group Ⅰ, Ⅱ period and Ⅲ, Ⅳ stage pregnancy rate there were no statistically significant difference (P>0.05), and the control group Ⅰ, Ⅱ period and Ⅲ, Ⅳ stage pregnancy rate there were no statistically significant difference (P>0.05); Two groups of laparoscopic surgery and open surgery pregnancy rates more statistically significant difference (P<0.05); Two groups of I, II period and III, IV stage pregnancy rate is a statistically significant difference (P<0.05); The observation group with the preoperative infertility after two years pregnancy rate compared with controls a statistically significant difference (P<0.05).Conclusion:The observation group the recurrence rate lower than those of the control group, but no statistical significance, traditional Chinese medicine that inhibit assured curative effects recurrence. The observation group pregnancy rate slightly lower than the control group, but this was not statistically significant difference (P>0.05). But in infertility patients, the observation group pregnancy rate is extremely significant higher than those in the control group (P<0.01). The observation group to short time after pregnancy in the control group and statistical significant difference (P<0.05). The TCM in help with the advantage of aspects, decrease the expect pregnancy time, improve vision in the fertility in patients after, more conducive to infertility or have fertility requirements of patients. |
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