| Objective:To explore the clinical therapeutic effect of catgut implantation at acupoint on perimenopausal syndrome and its mechanism.Methods:80patients met the diagnosis standard for postmenopausal women were randomly divided into catgut implantation group(treatment group) and the ordinary acupuncture group (control group),40cases in each group. Catgut implantation group includes27cases of the deficiency of liver and kidney, yang deficiency of spleen and kidney13cases, ordinary acupuncture group contains25and15cases in each type. The main acupoints choosen in treatment and control groups were as follows:Guan yuan, Qi hai, Zhong wan, Xia wan, Shen shu, San yinjiao.For the deficiency of liver and kidney type modified with liver shu point, yang deficiency of spleen and kidney with Zu sanli, Pi shu points. Two groups were both continuous treated4weeks as one therapeutic course, and a total of2cycle period. But catgut group was buried once a week, the control group was treated three times a week. Before and after the day treatment, Kupperman score and the changes of serum follicle-stimulating hormone (FSH), luteinizing hormone(LH), estradiol(E2)of the two groups were observed.Results:①The Kupperman score:The catgut group and acupuncture group of different syndrome types had significant differences in the MI of before and after treatment (P<0.01), there is no significant difference in the MI of after treatment between two groups and two types (P>0.05).②For each symptom score:The difference between the treatment group and control group in improving perimenopausal syndrome with hot flashes sweating, insomnia, irritability and fatigue is significant (P<0.01or P<0.05), while the control group have a good effect in perimenopausal syndrome with musculoskeletal pain and dizziness aspects (P<0.05); two groups have no obvious improvement in other perimenopausal syndrome (P>0.05).③Return visit:The catgut group and the contrl group in different syndrome types had significant differences between the MI of return visit and the MI of after treatment (P＜0.05or P<0.01), the two groups haue the same effect between groups. There is no significant difference in the MI of return visit between two groups and two types (P>0.05).④The overall efficacy comparison:The catgut group in yin deficiency of liver and kidney has an efficiency of79.17%, yang deficiency of spleen and kidney efficiency of92.86%; while the contrl guoup have an efficiency of84.62%and91.1%in each type. The total effective rate in catgut group is84.21%and86.49%in control group. There is no significant difference between two groups and two types(P>0.05).⑤the effect of the reproductive endocrine:The catgut group and the control group of different syndrome types had significant differences in the serum thyrotropin follicle hormone (FSH), serum luteinizing hormone (LH) and serum estradiol (E2) content between before and after treatment (P＜0.01), the two groups haue the same effect between groups (P<0.01). There is no significant difference in the serum thyrotropin follicle hormone (FSH), serum luteinizing hormone (LH) and serum estradiol (E2) content after treatment between two groups and two types.(P>0.05).Conclusions:①The catgut group and the normal acupuncture group can effectively improve the perimenopausal syndromes, especially in hot flashes sweating, insomnia, irritability and fatigue weakness. The short-term effect of two groups was significant, but the long-term effect was poor.②There is no significant difference in the improvement of perimenopausal syndrome between two groups and two types.③The two methods can reduce the levels of FSH and LH, while increase the level of E2. Its mechanism may be adjust the function of reproductive endocrine and the neutotransmitter content in the post-menopausal female.④There is no significant difference in the clinical therapeutic effect of perimenopausal syndrome between two groups, and it can be used for the patients to choose a variety treatment. |
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