The Study Of "Chinese Medicine Hair Restorer" Clinical And The Pharmacological Mechanism

Objective:This study examined the clinical curative effect of Chinese medicine hair restorer to the treatment of seborrheic alopecia, and investigate the efficacy and prescription of traditional Chinese medicine hair restorer, to provide further development of the experimental data of traditional Chinese medicine hair restorer. to become a test example of the industrialization of traditional Chinese medicine hair restorer.Methods:1. Collection of meet the standards patients with seborrheic alopecia100cases, randomly divided into two groups, the treatment group coated with traditional Chinese medicine hair restorer, blank group coated with placebo, treatment for4months. Each in the Chinese medicine hair restorer before and after treatment, the patients were recorded hair off the number, as well as improvement in symptoms, and adverse reactions.2. Use of testosterone propionate solution injection in mice, made into seborrheic hair removal model, at the same time, preventive treatment for mice smear Chinese medicine hair restorer, continuous60d. Determination of each group of animals serum testosterone (T) and estradiol (E2) levels by enzyme-linked immunosorbent assay,By the sebum Weight method for the determination local sebum secretion rate (SER).3. Animal model, the use of Na2S led the mice hair removal, to observe the hair restorer of traditional Chinese medicine and its prescription single herb extracts on the mouse body hair removal area, And by measuring the mice hair removal area neonatal hair length and weight changes, to investigate the prescription regularity. Result:1. Clinical study results show that:Test four months later, the treatment group the number of hair loss is significantly reduced, significant difference compared with the control group (P<0.05).The total effective rate of the treatment group62.2%, Significantly better than the blank control group which the total effective rate only31.25%, the treatment group had been reduced hair oil, dandruff, head itching and others associated symptoms, and no allergies and other adverse events occurred during the experiment.2. The pharmacodynamic mechanism results show that:Chinese medicine hair restorer can significantly reduce the level of serum T, elevated the serum E2levels of mice, regulated T/E2ratio, compared with model group significantly different (P<0.05).Chinese medicine hair restorer low-dose group was significantly lower rate of sebum secretion of mice, compared with model group significantly different (P<0.05)3. Prescription regularity studies have shown that:chinese medicine hair restorer the complete of prescription effect hair growth best, compared with the blank group, can significantly improve mice hair removal area hair growth, increase of mice hair removal area hair length and weight (P<0.05).the chinese medicine hair restorer group、Chinese Angelica group、Dried Ginger group、ChuanXiong group、Carthamus Tinctorius group, can significantly improve mice hair removal area hair weight, compared with the blank group (P<0.05). the chinese medicine hair restorer group、Dried Ginger group、PricklyashPeel group、 Fructus Vititcis group、Chinese Angelica group、ChuanXiong group、Carthamus Tinctorius group can improve mice hair removal area hair length, compared with the blank group, significant differences (P<0.05)Conclusion:1. Chinese medicine hair restorer for external use treatment of seborrheic alopecia have significant clinical effect, not only prevented hair loss and promoted the growth of hair, also to improve the patients of seborrheic alopecia with accompanied by symptoms, such as the hair oil, dandruff, head itching and so on. Its safety is good, worth and popularizing and applying.2. Chinese medicine hair restorer are significantly reduce serum testosterone levels and increased estradiol levels, reduce the secretion of skin oils, to improve the testosterone caused sex hormone disorders, to regulate the function of the sebaceous secretion, Very good effect to seborrheic hair loss caused by male hormones therapeutic.3. Chinese medicine hair restorer can promote the hair growth, increase of the new hair length and weight. the Chinese medicine hair restorer is reasonable, with promoting blood circulation to remove blood stasis, dispelling wind antipruritic effect. The sovereign medicinal Dried Ginger、 PricklyashPeel, is largest effects to the prescription. The minister drug ChuanXiong、Carthamus Tinctorius、Fructus Vititcis、Chinese Angelica, is better effects to the prescription, All drugs together to play a good synergistic effect。...