| Object ivesIn this study, a non-randomized control trial was conducted which aims to evaluate the influence of herbal extrat in current scientific researches. Based on the comparison of yang-deficiency symptom and fatigue symptom before and after treatment to evaluate the short term effect of the herbal extrat. In addition, we draw a comparison of the yang-deficiency symptom, fatigue symptom, psychological condition and the quality of life before treatment and after drug withdrawal for3month to evaluate the metaphase effect of the herbal extrat. Thus the effieacy of herbal extrat to yang-deficiency fatigue state of sub-health can be proved.MethodsThe study used a non-randomized, two-arm controlled design. We had totally observed80people of yang-deficiency fatigue state of sub-health. In which there were intervention group50cases and controlled groud30cases. According to the patient’s constitutional types and syndrome differentiation, we give the herbal extract to the intervention group for3months. At the same time, the people of controlled group only receive the health guidance. The evaluating tools included the Constitution in chinese medicine questionnaire, Fatigue scale-14(FS-14), the Brief Profile Of Mood States (BPOMS), the Zung Self-rating Depression Scale (SDS), the trait coping styles, the MOF SF-36questionnaire, and self-made TCM Syndromes questionnaire. The changes of the score of each quantity forms at before treatment,1-month,2-month,3-month treatment, and3months after suspension of medication were observed. The collected data were inputted to a database setup by SPSS18.0and analyzed with methods including descriptive analysis, pair-matching rank-sum test, two independent rank-sum test (when the variance was irregular), Repeated Measurement Data were performed by repetitive measurement and analysis of variance.ResultThere were no significant differences in the baseline level of gender and age (P≥0.05). Similarly, yang-deficiency foursub-scales, Fatigue scale-14(FS-14), the Brief Profile Of Mood States(BPOMS), the Zung Self-rating Depression Scale(SDS), the trait coping styles were no statistical significance between two groups (P≥0.05). We found that RP, VT, RE and MH dimension of SF-36were comparable (P≥0.05)1.As in the case of80people of yang-deficiency fatigue state of sub-health. There were22male and58female. Conclusion The incidence was higher in female. In80cases of yang-deficiency fatigue state of sub-health, there were67cases under age of50(83.8%) and13cases50years or older (16.3%). We can see that young adults were primary.2. In80cases of yang-deficiency fatigue state of sub-health, symptoms before ten were respectively:afraid cold, lassitude, easy to feel tired, cold extremities, easy to get tired with shortness of breath, thirst and want to drink hot, afraid of the wind, hypomnesia and attentional decline, intolerance to cold cool food, insomnia, palpitation.3. In the50cases included patients, in which there were36cases used personalized herbal extract. Analysis of drug use, medication before ten were respectively:biantiao ginseng, antler glue, prepared aconite root, astragalus, dodder, and which can normal functioning of spleen are atractylodes, poria cocos, zingiber making amomum, tangerine peel, baked licorice.4. The main effect analysis:①The results of repeated measures analysis showed that time effects of yang-deficiency foursub-scales were downward trend and there were signifieant(P<0.05). The results of two independent rank-sum test showed that after3-months treatment, the scores of yang-deficiency foursub-scales had no statistical difference(P≥0.05). However, When3-months after suspension of medication, there were statistical significance between the groups (P<0.05). The effectiveness of the treatment group improved mueh more than the control group.②The results of repeated measures analysis showed that time effects of the physical fatigue, the mental fatigue and the overall scores of fatigue were signifieant (P<0.05). Meanwhile, the effect of interaction between groups and time was statistically significant by multi—variate test of repetitive measure ANOVA (P<0.05). The results of two independent rank-sum test showed that after3-months treatment and3-months after suspension of medication, the scores of physical fatigue and the overall scores of fatigue had statistical difference (P<0.05). But the mental fatigue had no statistical difference (P≥0.05)5. The secondary outcome analysis:Two groups were evaluated again in psychological scale after3-months suspension of medication. The result showed that there were no statistical difference (P≥0.05) between two grouds in the Brief Profile Of Mood States(BPOMS), the Zung Self-rating Depression Scale (SDS) and the trait coping styles. There were statistically significant differences (P<0.05) before and after3-months suspension of medication treatment in the treatment group. And this scales’score were decline than before. Analysis of the quality of life:The result showed that there were no statistical difference (P≥0.05) between two grouds in RP, VT, RE and MH dimension of SF-36. There were statistically significant differences (P<0.05) before and after3-months suspension of medication treatment in the treatment group. And this dimensions’score were increased than before.6. Analysis of adverse reactions:symptoms in the gastrointestinal tract, including bloating, constipation and anorexia.Conclusion1. The yang-deficiency fatigue state of sub-health is mainly form by young female adults. Mainly performance in yang-deficiency and fatigue somatization. Most of them with a mental and emotional problems, and mainly perform negative coping.2. Professor Yang Zhi-Min’s therapeutic method of yang-deficiency fatigue state of sub-health usually value the Spleen and Kidney. Warming yang and invigorating yang at the same time nourishing yin is very important. That reflected the truth of interdependence between yin and yang, alternation yin and yang. The herbal of promoting middle warmer such as dried ginger, tangerine peel and baked licorice occupy an important position.3. The herbal extract can improve the deficiency of yang. It takes on action slowly, but there is still sustainable effect after stopping drug. The effect of herbal extract mainly embodies in one year later. In addition, herbal extract can improve patient fatigue state, and after stopping treatment remained stable.4. When the adverse reactions appear, depending on the circumstances to give guidance can reduce the incidence of adverse reactions. |
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