Expression Of Osteopontin In The Ovarian Serous Adenocarcinoma Tissue And Its Clinical Significance

Background and objective：ovarian cancer is a common malignant tumorof the female reproductive system,its incidence rate is at third,but the mortalityrate is at first. The ovarian serous adenocarcinoma is the most commonhistologic type of malignant ovarian tumors.Ovarian cancer usually occult,once symptoms belong to more advanced (stage III～IV),the5year survivalrate is less than30%,well below the70%～90%of early ovarian cancer.Themain reason is due to the lack of effective tumor markers in detection of tumorrecurrence and metastasis,judging tumor prognosis.Therefore,we urgent needlooking for effective tumor marker to identify those high-risk patients withdistant metastasis and recurrence,giving them effective treatment.It canimprove the survival rate and the quality of life of patients with ovarian cancer.Osteopontin (OPN) is a secreted phosphorylated glycoprotein.The recentstudies have found it has close relationship with the growth, proliferation andinvasion, metastasis of tumor cell. It has important link between the expressionlevel of OPN in ovary malignant tumor tissue and tumor screening, diseaseforecast and prognosis.Thus,it offers a new index for malignant ovarian tumorearly diagnosis, monitoring recurrence and prognosis judgement.Methods： The expressions of OPN in70cases of ovarian serousadenocarcinoma tissues,22cases of ovarian serous adenoma tissues, and15cases of normal ovarian tissues were detected by immunohistochemistrymethod.Results：1.The positive expression rate of OPN was82.9%in ovarianserous adenocarcinoma tissues, The positive expression rate of OPN was22.7% in ovarian s serous adenoma tissues.The positive expression rate of OPN inovarian serous adenocarcinoma tissues is much higher than those in ovarianserous adenoma tissues(P<0.05).2.The positive expression rate of OPN innomal ovarian tissues is13.3%, The positive expression rate of OPN in ovarianserous adenocarcinoma tissues is much higher than those in nomal ovariantissues (P<0.05).3.The positive expression rates of OPN in stage Ⅰ，stage Ⅱ，stage Ⅲ，stage Ⅳ ovarian serous adenocarcinoma tumor tissueswas60.0％,was76.2％, was96.2％, and100.0％.The positive rate of OPN expression instageⅢ tumor tissues was dramatically higher than that in stage Ⅰ(P<0.05).4.The positive rate of OPN expression in stage Ⅳtumor tissues wasdramatically higher than that in stage Ⅰ(P<0.05). The positive expression ratesof OPN in early stage (stageⅠ～stageⅡ)ovarian serous adenocarcinomatumor tissues was69.4％, the late stage (stageⅢ～stageⅣ)is97.1%, Thepositive rate of OPN expression in late stage tumor tissues was dramaticallyhigher than that in early stage (P<0.05).5.The positive expression rates of OPNin G1，G2，and G3ovarian serous adenocarcinoma tumor tissues were74.1％,80.0％,100.0％, It was dramatically higher in G3tumor tissues than thatin G1(P<0.05).6.The positive expression rate of OPN in ovarian serousadenocarcinoma tumor with ascites tissues is95.2%, The positive expressionrate of OPN in ovarian serous adenocarcinoma tumor without ascites tissues is95.2%.The positive expression rate of OPN in ovarian serous adenocarcinomatumor with ascites tissues is dramatically higher than that in tumor tissueswithout ascites(P<0.05).7.The positive expression rate of OPN in age greaterthan50years of ovarian serous adenocarcinoma tumor tissues is90.7%, Thepositive expression rate of OPN in younger than or equal to50years of ovarianserous adenocarcinoma tumor tissues is70.4%.The positive rate of OPNexpression in younger than or equal to50years of ovarian serous is not dramatically higher than that in greater than50years(P＞0.05).Conclusion：1.The positive expression rate of OPN in ovarian serouscystadenocarcinoma tissues is much higher than those in ovarian serouscystadenoma tissues and nomal ovarian tissues(P<0.05).2.There wascorrelation between the positive expression rate of OPN with pathologicalgrading and clinical stages.3.the later clinical stage and the worsedifferentiation of ovarian serous adenocarcinoma,the stronger positiveexpression rate of OPN.4.There was no relation between OPN and the age ofthe patients.5.Overexpression of OPN may has the relationship with thedevelopment,invasion and metastasis of ovarian serous adenocarcinom. Itspotential clinical significance can be used as a prognostic marker in ovariancancer patients.