Platelet Parameters Among Ich, Ci And High Risk Groups That May Lead To Stroke

Objective:To investigate the difference in platelet parameters among ICH, CI and high risk groups that may lead to stroke. ICH patients are divided into two groups according to the volume of hemorrhage and GCS respectively. CI patients are also separated into two groups based on whether lacunar infarction occurred or not. Platelet parameters are then compared between each subgroup.Method:Acute ICH and CI patients who are admitted to our hospital within24hours after the onset of symptoms are chosen as the main object of study. Hypertension, diabetes mellitus and hyperlipidemia patients were selected as the subject that have the high risk of developping stroke(high risk groups). The blood routine test (incuded PLT, MPV,PDW) was measured within24hours after patients were admitted to hospital. All these results were compared with the control group.Result:MPV was significantly raised among ICH, CI and high risk groups (included hypertension, diabetes mellitus and hyperlipidemia group) compared with healthy control subject. No significance was found among ICH, CI and high risk groups. PLT was significantly declined in ICH, CI and high risk groups. No significance was found in PLT among ICH, CI and high risk groups. There was no significant difference in PDW in all the studied main groups and subgroups.PLT of the group that the volume more than30ml was lower than the group which is less than30ml not significantly, both the two groups’PLT was significantly lower than control group, and MPV was higher than control group significantly. The PLT of groups with GCS<8and>8were both lower than control group significantly, and the group of GCS<8was lower than the group with GCS>8not significantly, the GCS>8group’ MPV significantly higher than the control group. The PLT of lacunar infarction and not lacunar infarction group were both lower than control group significantly, the PLT of the not lacunar infarction group was lower than lacunar infarction group not significantly, MPV of the both group was higher than control group, but only the not lacunar infarction group has statistical significance.At last,our result supports the point that there is negative correlation between MPV and PLT.Conclusion:ICH or CI patients may coexist with one or more cerebrovascular risk factors for a long time before the onset, such as hypertension, hyperlipidemia, diabetes mellitus, atherosclerosis, fat, metabolic syndrome and so on. As a result, platelet may be activated before stroke, and MPV may increase while PLT may decrease. After ICH or CI occurs, PLT would drop rapidly and obviously. This finding have led to the conclusion that the increased MPV values were probably pre-existent to the ICH and CI, and were potentially involved in the genesis of the diseases. Thus, among the many parameters provided by whole blood count, MPV should not be disregarded, and its increment should suggest a careful assessment of cerebrovascular risk.