Huoxue Huazhuo Capsule In The Treatment Of Hyperlipidemia Experimental Study

Objective This experiment by feeding high fat diet inducedhyperlipidemia rat model, to study the preventive effect of HuoxueHuazhuo capsule, and the altitude of the effect between, discuss itsmechanism of action.Methods According to elevation is divided into different Xining group（2260m elevation） and the Yushu group （3681m elevation）, two groupsof experimental design, animal number, grouping and operation are thesame. Choose health of48male Wisatar rats were randomly divided into6groups, each group of8. Respectively: blank group, model group,positive drug group, Huoxue Huazhuo capsule big, in, small dose group,except the blank group,othern groups were fed a high fat diet; afterinjecting, positive drug group with Xuezhikang treatment, dosage of0.25g kg^-1; Huoxue Huazhuo capsule in group of small dose isrespectively0.75,1.5,3g kg^-1; model group with the same volume ofsaline. Weekly weigh animal weight, adjust the amount of gastric lavage.After treatment for28days, blood from the abdominal aorta, withurethane anesthetized animal, blood from the abdominal aorta, and liver,weighing. The effect of Huoxue Huazhuo Capsule on biochemicalindexes, and each weight, liver index author.Results1. effects on serum lipids in rats fed with the experimentalconditions were observed for5weeks, model group and blank groupblood, serum TC and TG increased significantly （P<0.05）, description ofmodeling success. After treatment for4weeks later, Xining, Yushu two group of Huoxue Huazhuo capsule in different dosage groups of RatsLipid compared with the model group, TC, TG, LDL-C, APOB werereduced in different degree, and the HDL-C, APOA I increased to variousdegrees, indicates that blood Huazhuo capsule can regulate lipidmetabolism disorder and enhanced in vivo cholesterol removal function;and positive drug group, two groups of Huoxue Huazhuo capsuledecreased the elevated LDL-C, APOAI, HDL-C effect of XuezhikangCapsule （P<0.05）. High dose group, low dose group was better than in.The two results show Huoxue Huazhuo capsule increased or decreasedeach lipid levels, the effect was statistically significant; but the tworesults are not statistically significant.2. on body weight, liver index of the rats with experimentalhyperlipidemia rat body weight, liver index changes have significantchange, Xining,Yushu two group of Huoxue Huazhuo capsule, in the highdose group and model group rats liver weight, liver index decreasedsignificantly （P<0.05）, especially in middle dose group significantly.Description of Huoxue Huazhuo capsule, in the high dose group, canslow down the growth rate decreased liver, liver index reduce liverdamage, the effect may be enhanced through liver cell output or TGtransformation, reduce liver intracellular accumulation of TG in purpose,but experimental dose is too big or too small to reduce the liver index, theeffect is not obvious; and positive drug group comparison, no significant.The two results in the application of blood-activating and Huazhuocapsule group after rat weight and liver index was decreased, the effectwas statistically significant. But the two results, no statistical significance.Conclusion1.Huoxue Huazhuo Capsule on high altitude area, fed a highfat diet induced lipid metabolic disturbance of rats with prevention andregulation effect, lowering lipid levels, thereby reducing cholesterol in the arterial wall deposition, prevention of atherosclerosis. Large, middle dosegroup was better than that of small dose group; and the two area effect isnot statistically significant.2. improves hyperlipidemia rat liver function,regulating liver in the lipoprotein metabolism enzyme system disorders,and prevention and treatment of fatty liver in mice. Effect of XuezhikangCapsule, in the large dose group, effect is apparent, but not obviousdose-effect relationship. Two area effect is not statistically significant.3the two results of the Yushu and Xining each dosage group comparedwith obvious effect, where APOA, TG high, in three, low dose group,low dose group, TC, HDL dose group were lower than the Xining groupdecreased obviously.