| Objective:To observe the change of the plasma IL-4.IL-10. IFN-γcytokine levels and EOS,pulmonary function before and after treatment inpatients with asthma. Meanwhile, the mechanism and role of ComprehensiveExternal treatment (Acupoint injection,Plum blossom needle pricking andacupoint ventouse) to treat asthma and regulate Th1/Th2cell balance wasinvestigated. Then the efficacy of Comprehensive External treatment wasevaluated. We could provide the important basis for the clinical and developthe advantages of traditional Chinese and Western medicine combined to treatasthma.Methods: Numbered according to the patients visiting time, seventy-fivepatients who met the criterion of chronicity persistent period of bronchialasthma were randomly divided into three groups. They were divided into thecontrol group A, the control group B and the treatment group. Each groupcontained twenty-five cases. The control group A was treated through routinemethod according to2008guide for asthma preventionand cure. The controlgroup B was treated by acupoint injection with BCG-PSN on the basis of theconventional treatment, this operation was done one time every other day.Thetreatment group were treated by acupoint injection with BCG-PSN(BilateralDingchuan acupoint),plum blossom needle pricking (Dazhui, Bilateral Feishu,Geshu, Pishu, Shenshu acupoint) and acupoint ventouse (Dazhui, BilateralFeishu, Geshu,Pishu, Shenshu acupoint) on the basis of the conventionaltreatment,This operation was done one time every other day too. The totaltreatment course of three groups was forty days. The patients' lung functionand EOS counts were observated and the concentration of IL-4, IL-10, IFN-γwas determined by ELISA before and after treatment in each group. Thendraw a Excel table and use Statistical software to count data. Result:1Compare of total curative effect in three groupsEach group includes wenty-five cases, in control group A the number ofclinical control was7, markedly effective was5, improvement was4andinvalid was9. Total effective rate of the treatment group was64%. In controlgroup B, the number of clinical control was8, markedly effective was8,improvement was5and invalid was4, total effective rate was84%. In thecontrol group, the number of clinical control was9, markedly effective was10,improvement was4and invalid was2, total effective rate was92%.There wasobviously changes between the treatment group and the control group A(P<0.05).2Compare pulmonary function in three groupsFEV1/pred was64.25±12.32before treatment and69.27±12.91aftertreatment in the control group A. It was64.36±12.89and71.18±11.46in thecontrol group B. And It was63.07±11.63and75.25±9.94in the treatmentgroup. Compared the three groups, the treatment group was better than thecontrol group A and B (P<0.05), but there was no obviously differencebetween the the control group A and the control group B (P>0.05); FEV1/FVCwas63.53±11.64before treatment and69.60±13.08after treatment in thecontrol group A. It was64.17±13.53and72.13±12.31in the control group B.And It was61.22±12.36and75.40±8.37in the treatment group. Comparedthe three groups, the treatment group was better than the control group A andB(P<0.05), but there was no obviously difference between the control group Aand the control group B(P>0.05); PEF variation rate was29.08±5.95beforetreatment and20.04±10.94after treatment in the control group A. It was28.95±5.89and17.41±10.63in the control group B. And It was30.06±6.68and14.99±7.27in the treatment group. Compared the three groups, thetreatment group was better than the control group A and B (P<0.05). Therewas no obviously difference between the control group A and the controlgroup B (P>0.05). But there were greatly difference in FEV1/pred,FEV1/FVC and PEF variation rate between before treatment and after treatment in each group,(P<0.05).3Compare the points of symptoms and signs in three groupsIn the control group A, there was17.36±4.57points before treatmentand12.00±6.88points after treatment. It was16.88±4.69and8.56±6.18inthe control group B. And It was18.16±4.36and6.24±5.04in the treatmentgroup. Compared the three groups, It had been obviously difference (p<0.05),there was also obviously difference between before treatment and aftertreatment in each group,(P<0.05).4Compare the counts of EOS in three groupsIn the control group A, the counts of EOS was0.52±0.22beforetreatment and0.32±0.14after treatment. It was0.55±0.20and0.29±0.15inthe control group B. And It was0.55±0.22and0.23±0.12in the treatmentgroup. Compared the three groups, there was difference between beforetreatment and after treatment in each group (P<0.05).There ware obviouslydifferen-ces between the treatment group and the control group A (p<0.05),but there was no obviously difference between the treatment group and thecontrol group B (p>0.05).5Compare the immune parameters in three groupsIn the control group A,the concentration of IFN-γ was4.87±2.11beforetreatment and8.24±4.58after treatment. It was4.72±2.45and9.07±4.20inthe control group B. And It was4.59±2.38and10.63±4.41in the treatmentgroup. Compared the three groups, there was obviously difference betweeneach group,(P<0.05). The concentration of IL-4was57.55±14.97beforetreatment and40.24±18.13after treatment in the control group A. It was58.11±16.96and33.98±18.10in the control group B. And It was51.19±14.28and30.84±12.65in the treatment group.There was obviouslydifference between each group (P<0.05). The concentration of IL-10was9.97±3.62before treatment and10.36±3.75after treatment in the control groupA. It was9.52±3.02and10.08±3.15in the control group B. And It was9.34±2.85and10.10±3.19in the treat-ment group.There was no obviouslydifference between each group (P>0.05). But there were greatly difference in IFN-γ, IL-4and IL-10between before treatment and after treatment in eachgroup,(P<0.05).6Compare securitis in the treatment of asthma in three groupsTwenty-five cases of the control group A, the number of1Level was19patients,2Level was3patients,3Level was3patients;in the control group B,the number of1Level was21patients,2Level was2patients,3Level was2patients;in the treatment group, the number of1Level was21patients,2Levelwas2patients,3Level was2patients,There was no obviously differencebetween each group(P>0.05). All the groups were relatively safe.Conclusion:1Comprehensive External treatment (Acupoi-nt Injection,Plum blossom needle pricking and acupoint ventouse) joint routine treatmentwas more efctive than only routine treatment.2Comprehensive Externaltreatment joint routine treatment was able to increase IFN-γ levels and lowerIL-4,EOS levels markedly, It has a regulating role in asthma patients Th1/Th2immune imbalance,but enhance the role of IL-10has yet to be studied further.3By regulating Th1/Th2cell balance, Comprehensive External treatmentimprove patients' clinical symptoms, improve organism immunity, improvelung function and degrad airway' hyper reactivity.This method achievelong-term control of asthma purpose, both to reduce the economic burden ofpatients, but also easy to operate, and worthy of promotion. |
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