Coronary Heart Disease Multi-factor Correlation Analysis

Objective: The rates of morbidity and mortality of coronary heart disease(CHD) are increasing in China. There are a great many risk factors that cancause coronary heart disease including lipid factors and non-lipid factors.Lipid variables comprise total cholesterol (TC), triglyceride (TG), high densitylipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein AI(ApoA-I), apolipoprotein B (ApoB), lipoprotein a (Lpa), apolipoprotein CIII(ApoC-III) and so on. Non-lipid variables includes age, gender, family history,hypertension, diabetes and smoking. In this study, we collected222patientswith coronary heart disease who diagnosed by coronary angiographies. Wedivided the patients into the mild group and the severe group based on theseverity of the disease.Methods: We elucidated and classify the severity of coronary arterydisease by Gensini coronary scoring system. We detected the lipids, glucose,apoC-III in plasma by automatic biochemical analyzer, and analyze the datawith SPSS software.Results:1The correlation of the baseline characteristics and past medical historyand the extent of coronary lesionsAccording to the score of coronary artery, patients were divided into mildgroup (the score<22) and severe group (the score>22). We observed thedifferences of age, gender, blood pressure and smoking between the twogroups by Student t test, nonparametric test or chi-square test. The resultsindicate that the age of patients in the severe group is elder than patients in themild group (P<0.05). There is no difference in smoking between the twogroups. We detected the difference of past medical history includinghypertension and diabetes in the two groups by chi-square test. The results suggested that the proportion of the patients with hypertension in the severegroup (76.6%) is higher than that in the mild group (57.8%)(P<0.05). Theproportion of the patients with diabetes in the severe group (28.7%) is higherthan that in the mild group (17.2%)(P<0.05).2The correlation of the lipids and fasting glucose and the extent ofcoronary lesionsWe observed the differences of TC, TG, HDL, LDL, Glu between the twogroups by Student t test or nonparametric test. The results indicate that there isno difference between the two groups.3The correlation of the apolipoprotein in plasma and the extent ofcoronary lesionsWe observed the differences of ApoA-I, ApoB, Lpa, ApoC-III betweenthe two groups by Student t test or nonparametric test. The results showed thatplasma ApoA-I and Lpa levels in patients with mild and severe coronary heartdisease are different. The level of ApoA-I in the mild group is higher than thatin the severe group (P<0.05). The level of Lpa in the severe group is higherthan in the mild group (P<0.05).4The correlation of the risk factors and the extent of coronary lesionsAfter adjusting the age and gender differences, we detected thecorrelation between the severity of coronary heart disease and age, gender,hypertension, hyperlipidemia, diabetes, TC, TG, HDL, LDL, Glu, ApoA-I,ApoB, Lpa, ApoC-III by Logistic regression. The results showed that there isa positive correlation between the severity of coronary heart disease and age,diabetes, abnormal HDL, respectively. Therefore, age, diabetes and abnormalHDL level are risk factors of coronary heart disease.5The correlation between the plasma lipids and ApoC-IIIWe tested whether the level of TC, TG, HDL, LDL, ApoA-I, ApoB, Lpa,Glu and ApoC-III are correlated with each other by Spearman correlation. Theresults indicated that there is a positive correlation between each other.Conclusions:1The age, hypertension and diabetes of patients are positive correlation with severity of coronary heart disease.2The level of ApoA-I in the mild group is higher than that in the severegroup. The level of Lpa in the severe group is higher than in the mildgroup.3Age, a history of diabetes and abnormal HDL level are risk factors fordevelopment of coronary heart disease.4There is a positive correlation between TC, TG and ApoC-III.