| Objective: To discuss the relationship among the level of serum metalloproteinase -9(MMP-9) ,hs-CRP, plasma lipids (including cholesterol (TC), triglyceridemia(TG), high density lipoprotein-cholesterol(HDL-c), low density lipoprotein-cholesterol(lDL-c) and the number of the narrow main coronary artery of coronary atherosclerotic heart dtsease(CAD) patients.Methods : ninety-nine patients are divided into acute myecarJial infarction (AMI)group (n=26),unstable angina pecioris(UAP) grcup(!r 33) stable angina pectoris(SAP) group(n=20) and control group(n=20). The enzyme-linked immunosorbent assay(ELISA) was used to detect the level of serum MMP-9.And oxidase-peroxidase method was used to detect the level of plasma lipids.Coronary arteriography was used to analyze the number of the narrow main coronary artery.Finally,the relationship among them was annJyzcd.Results: 1. The comparison among all patients: 1.1 The MMP-9 levels of AMI group and UAP group were obviously higher than those of the SAP group and control group(p<0.05).1.2 The MMP-9 level of AMI group was higher than that of UAP group(p<0.05). 1.3 The differences between the MMP-9 levels of SAP group and control group were not significant.(P>0,05). 2. The comparison among all patients: 2.1 The hs-CRP levels of AMI group and UAP group were obviously higher than those of the SAP group and control group(p<0.05).2.2 The hs-CRP level of AMI group was higher than that of UAP group(p<0.05) .2.3 The differences between the hs-CRP levels of SAP group and control group were not significant.(P>0.05). 3. The differences between the number of narrow coronary artery of AMI group and UAP group is not significant. (p>0.05),the others is significantAThe MMP-9 hs-CRP level of CAD patients was not related to the number of narrow main coronary artery (r=0.386,p=0.07; r=0.287, p=0.31). 5. The MMP-9 Jevel was negatively related to the level ofTCU LDL-c(r=-0.275,p=0.008;r=-0.382, p=0.003), and was not correlated with the level of TG.HDL-C (r=-1.143r p=0.29;F=Q.0.085, p-0.565). 6. .The hs-CRP level was negatively related to the level ofTC> LDL-c (r=-0. 378, p=0. 015; r-0.485, p=0. 010), and was not correlated with the level ofTG5HDL-c(r=-l. 289, p=0. 59; r=0. 015, p~0. 585) 7.The number of narrow main coronary artery is not related with the level of plasma lipids: TC : r=-0.012 , p=0.465 : TG: r=-0.105 , p=0.448 ; HDL-c:r=0.078, p=0.609; LDL-c:r=0.00l,p=0.992. 8. The level of plasura TC and LDL-c of AMI group is lower than that of UAPgroup,the level of UAP group id lower than the control group and SAP group(P<0.05),I!ovy,r籩r,the level of plasma TG and HDL-c is of no regularity.Conclusion: MMP-9 N hs-CRP can be used as the marker of wuiiab'e coronary artery plaques. MMP^ hs-CRP is an index of the emergence and degree of CAD. The higher the lever of MMP-9 and hs-CRP is , the grea'^r the seriousness of ACS is. Moreover,we find that the le%;el of serum lvLMP-9 and hs-CRP is negatively related wita plasma TC\ LDL-c and is nol related -.vit'i that of TGs HDL-c. However,the number of narrow main coronary artery is noi related with the seriousness of CAD and the level of MMP-9 N hs-CRP and of plasma lipids. The level of plasma TC and LDL-c of AMI group is lower than that of UAPgroup,the level of UAP group id lower than the control group and SAP group(P<0.05).However,the level of plasma TG and HDL-c is of no regularity. So,we can check up the level of MMP-9 and hs-CRPto realize the earlier knowledge v diagnosis > treatment and the future of ACS patients. |
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