| Objective:To observe and evaluate the therapeutic effect of Kuntai Capsule on decreasing ovarian reserve and Premature ovarian failure, and provide scientific evidence for the clinical usage of Kuntai Capsule.Methods:1.Select the patients with Decreasing ovarian reserve/premature ovarian failure, according to asthenic yin causing excessive pyrexia,60 cases were observed. The are divided into two groups:A group of Decreasing ovarian reserve(10IU/L< FSH≤40IU/L)and B group of premature ovarian failure (FSH>40 IU/L). Each group patients are further randomly divided into 2 teams, respectively, Kuntai Capsule treatment group and artificial cycle control group. The usage Methods of Kuntai Capsule:4 capsules/time,3 times/day, per os half an hour after meals, for three months. The control group (estradiol valerate tablets lm g/tablets), a night, taking half an hour after dinner, for 21 consecutive days, the last day for 10 days plus medroxyprogesterone acetate 10mg/d, stop drugs was period, from the 5th day of menstruation re-use; without menstrual onset,7 days after stopping to take the next cycle by the above method.3 cycles of treatment. All patients are evaluated at physical sign integrals, syndrome integrals; variations of sex hormones and changes of ovarian volume, endometrial thickness, follicle number and ovarian artery blood flow (RI, PVS) by color Doppler ultrasound.Results:1.After treatment, symptoms were significantly improved com-pared with before, the results are significantly different (P<0.01), and the two groups in the KI score after treatment wa s no significant difference (P>0.05), suggest the efficacy of two treatment methods considerable. The treatment group improved significantly in terms of sensory abnormalities (P<0.01),and improvement of dizziness and palpitations were also more significantly (P<0.05). In the control group the treatment of urinary symptoms was sup e rior to the treat-ment group (P<0.01), and improving symptom of insomnia and bone and joint pain was significantly(P<0.05).2.A group:The FSH, LH and E2 were descend than those before in two groups, and it was significantly different (P<0.05), hormone levels after treatment was no significant difference in two teams (P>0.05). B group:In treatment group, the FSH,LH levels decreased compared with that before, but no significant difference (P>0.05), E2 levels increased over the previous (P<0.05); In the control group, The FSH was significantly decreased, the difference was signi-ficant (P<O.01), LH levels was slightly down compared to before, there was no significant difference (P> 0.05), E2 levels than the previous increase, the difference was significant (P<0.05). After treatment, FSH levels were significantly different (P<0.05) in the two groups, and LH and E2 levels showed no significant (P>0.05).3. A group:After treatment, the uterine size, ovarian volume, number of follicles were no significant changes than before in the two groups(P>0.05); endometrial thickness compared with before, both groups increased, there was significant difference (P<0.05), and the control group increased compared with treatment group, the difference was significant (P<0.05); The resistance index (RI) did not change significantly in treatment group (P>0.05);But in the control group, it's descent than before, the difference was significant (P<0.05), but the RI in both groups after treatment was no significant difference (P>0.05); The PSV values of two groups patients are increased than before after treatment (P<0.05), and between the two groups after treatment, difference was no significant (P>0.05). B group:In the control group, the uterine size was larger than before after treatment (P<0.05), but the difference compared with the treatment group, no significant (P>0.05); other indices such as ovarian volume, endometrial thickness, follicle number and ovarian artery blood flow(RI, PVS), there was no significant difference compared with before in the two groups (P>0.05).Conclusion:Treatment with Kuntai capsule on decreasing ovarian reserve/ premature ovarian failure can significantly improve symptoms of patients, and its overall effect was comparable with hormone replacement treatment, with side effects safe, and provides a new choice for who are reluctant to adopt hormone replacement therapy.In patients with Decreasing ovarian reserve, the effect of Kuntai capsule in improving the status of the endocrine and blood flow is similar to the hormone replacement therapy, indicating that the earlier the treatment was undergone, that is in the early rise time in FSH and LH, the more ideal the clinical effect was.In patients with premature ovarian failure, the therapeutic effect of Kuh Tai Capsule on improving endocrine function was worse than the endocrine hormone replacement treatment. |
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