| Background:The breast is a symbol of female beauty. It is a beautiful dream of the human that through an injection way easily to change local shape of the body, especiely making the breast augmentation beauty. Just for this, many products of injections coming to being used. Except hydrophilic polyacrylamide gel was more widely used a few years ago there are still many other products to be widely used such as HA, HA mixture and so on. However, due to historical limitations of scientific development and a variety of factors, such the technique of injection and so on, unfortunately leading to a variety of complications which can not be avoided, more serious complications occurred in the breast augmentation caused by injection, some of these cases even were resulted in the loss of the breasts. The complications and side effects of breast augmentation caused by injection has been gotten great concern by the people. To PAAG, for example, the exact cases of injection formed in the breast cavity of one or more complete, more easily handled. But more and more space in the breast and chest organization formed in different sizes scattered cystic mass or series, or even walk dispersed far outside the abdominal wall to the breast, back and forearms and other parts. Distributed walk, outside theabdominal wall as far as the breast, back and other parts of forearm. April 30,2006, the State Food and Drug Administration issued a document:Request a full cessation of polyacrylamide hydrogel production, sale and use. However, according to statistics, as of 2005, China had more than 30 million people were injected with PAAG breast. Faced with such a large patient population, how to treat complications of injected is plastic surgeon face. Complication in the treatment of breast injection method, the main aspiration issimple and clear cut under direct vision. The disadvantage is not exactly clear foreign and necrotic tissue, resulting in many cases repeated surgery。Removal of excess breast tissue or even the whole. So how to clean out the injection material and necrosis tissues of the breast caused by injection effectively and restoring or remodeling chest & breast tissues and reshaping the perfect breast shape is a pressing issue we are facing.Clinical application of mature technologies such as dialysis, hemodialysis, peritoneal dialysis, intestinal dialysis, microdialysis, in different areas can remove harmful substances, inhibit inflammation and promote wound healing the body. In 1984, Professor Zhu Zhixiang dialysis local tissue flap transplantation can promote the survival of burn. Therefore we assume that the local injections of micro dialysis treatment if results are obvious and superior to conventional treatment.Objective:This issue is divided into two parts:first, animal experiments study the effectiveness of local microdialysis, a preliminary study of its mechanism of action; second, the mechanism of clinical validation of therapeutic study injections of local breast complications of dialysis effectiveness.Methods:Part 1 1.12 New Zealand white rabbits were randomly divided into the experimental group and the control group, established animal model of local damage.2.Experimental group partial use of microdialysis dialysate drainage; control group using saline irrigation drainage.3. Wounds were observed general changes in experimental animals.4. Two group fluid drainage in general.5. Collect two sets of drainage fluid were measured after reperfusion 4h, 10h, 20h,30h,45h drainage of fluid osmotic pressure, Na+, K+, CL-, Ca2+ and IL-1, IL-6, IL-8, TNF-αconcentration.6. Statistical analysis:Analysis of statistical software with SPSS17.0. Analysis of variance with repeated measures design.The experimental group and the control group, the concentration of the control group were compared between the two groups separate effects of using two independent sample t test or t 'test (Heterogeneity of variance), the time between the use of One-way ANOVA or Welch test (variance missing time). Select the significance levelα=0.05.Part 21. Clinical randomly selected 33 patients with breast injection breast 65.2. Line areola incision, clear injection material, in place under the auspices of residual breast dialysis drainage, closed wound.3. Continued 24～72h of dialysis fluid. An average of each breast about 800ml/24h. Discontinuous control (about 4 hours) drainage of fluid out of the folder.4. Reoperation. According to the patients requirements, leave the body or direct closure of incision.Result:Part 1 1.Local dialysis ion balance for the experimental group2.Local dialysis to reduce IL-1, IL-6, IL-8 concentration, while increasing conce- ntrations of TNF-a3. Local dialysis can improve the environment is not conducive to tissue growth and promote tissue healing4. Statistical analysis was statistically significant.Part 21.Application of new PTFE/silicone rubber composite made of a new type of ultra-smooth biomimetic micro dialysis catheter, access to the national utility model patents. The biggest characteristic of dialysis tube is hydrophobic oleophobic, no plugging and no adhesion. Reduce the chance of infection and to ensure the success of micro drainage during the dialysis treatment.2. A total of 65 breast complications caused by injection of 33 cases was treated using this local micro-dialysis.After following up for a 6 month-5 years period of observation showed:3 cases or within outer quadrant of the breast appears isolated within 1cm nodules, and the remaining breast shape normal.Concluding:(1) The using of local dialysis in the local parts of the body effected directly on the local tissues of this partial body including to promote the local blood circulation, metabolism, to maximize dialysis and drainage foreign bodie and tissue necrosis out of the body, to reduce accumulation of necrotic tissue and foreign bodies, to promote the degenerative tissue survival, The results of in the complication treatment of breast augmentation caused by injection also suported this issue.(2) The application of the micro-dialysis technique in the treatment of complications of the breast augmentation caused by injected is effective, and more breast tissues can been retained for reshaping the breast good shape.64 of 33 cases of breast implants successfully placed and reshape the breasts of beautiful forms. |
PDF Full Text Request