The Clinical Observation Of Jia Jian Wenjing Decoction Treatment On Primary Dysmenorrhea With Cold-stagnation Blood-stasis Syndrome

Primary dysmenorrhea is a common gynecological disease in clinic, Professor Zhang Lijun always use jia jian wen jing decoction in the treatment of primary dysmenorrhea. Prescription form:Puhuang 10g, Wulingzhi 10g, Xu Changqing 10g, Aiye 10g, Wuzhuyu 10g, Xiaohuixiang 10g, Guizhi 6g, Baisao 10g, Gancao 6g, Chuan Xiong 10g, DangGui10g, Chuanlianzi10g, Xiangfu10g, Ezhu10g; Tongjingbao Granule (YueYueShu) is a clinical gynecological medicine on the treatment of primary dysmenorrhea。It can warm meridian and promote Qi action to relieve pain。Objective:According the clinical trials of jia jian wen jing decoction by treating primary dysmenorrhea, to evaluate the clinical efficacy and safety in order to widely use jia jian wen jing decoction in clinical of Gynecology.Methods:The cases meet the diagnosis of primary dysmenorrhea and cold-stagnation blood-stasis syndrome divided into treatment group and control group, treatment group 32 cases,20 cases of the control group, respectively, three menstrual cycle treatment, the efficacy and safety assessment are recorded at the end of the medication, The treatment group received oral decoction of jia jian wenjing decoction ang the control group were given oral TongJignBao Granule, each month by 5 days before the start of menstrual cycle begin to treat, medication for 7 days (test group:jia jian Wenjing decoction, one packet each time, two times a day; control group: TongJingBao Granule, lpacket/time,2 times/day), two drugs are comparable in function. efficacy of clinical Indicators:key indicators:(1) score of dysmenorrhea symptom (2) pain degree of dysmenorrhea (VAS)Secondary indicators:(1) efficacy rate of dysmenorrhea (2) cure rat of syndromes TCM。Efficacy recording method:patients were administered two groups were observed and recorded before and after each treatment cycle, pain degree of dysmenorrhea (VAS), score ofdysmenorrhea symptom, statistics scores and in accordance with relevant standards to determine the efficacy of efficacy evaluation, calculate the efficient rates and the cure Rates between the two groups, compare the score of dysmenorrheasymptom before and after treatment, after each treatment cycle, after treatment. Follow-up for three months after the end of the experiment, recorded the efficacy of TCM syndrome cure rate at the third month。Safety indicators:laboratory parameters:Blood analysis,Urine analysis and stool analysis,liver function and kidney function, electrocardiogram. Normal vital signs:weight, breathe pulse, blood pressure.Recording method:Record the related indicatorsrespectively,before the first cycle and at the end of the third the detection.Results:1. The dysmenorrhea symptom scores of the group of jia jian Wenjing decoction and the group of Tongjingbao Granular are respectivly compared before and after treatment, according the statistical analysis, P<0.01, the comparisons have significant difference. The dysmenorrhea symptom score after each treatment cycle in the same group are compared by statistical analysis, P <0.05, the comparisons have significant difference. The dysmenorrhea symptom scores of two groups after treatment were compared by statistical analysis,P> 0.05, the comparisons have no significant difference.2. The pain degree ofdysmenorrhoea of the group of jia jian Wenjing decoction and the group of Tongjingbao Granular are respectivly compared before and after treatment, statistical analysis, P<0.01, the comparisons have significant difference;, The pain degree of dysmenorrhoea after each treatment cycle in the same group are compared by statistical analysis, P<0.05, the comparisons have significant difference. Comparing the pain degree of dysmenorrhoea of two groups after treatment by statistical analysis, P> 0.05, the comparisions have no significant difference.3. On the efficacy rate of dysmenorrhea, the treatment group of 32 patients,2 people have no effect, the effective rate was 93.75% in the control group 20 cases,3 people have no effect, the effective rate was 85.00%. Comparing the difference between the efficiency rate by statistical analysis, P> 0.05, no significant differences between them.4. On the cure rat of syndromes TCM,The group of jiajian Wenjing decoction enrolled 32 patients,12 people pain disappeard at the end of the experiment (cure),30 people pain relieved (including cured); the cure rate is 37.50% follow-up 3 months later,10 people pain still disappeared (cure), relapse 2 people, but the degree were remisse, the cure rate of the thried month was 31,25%; statistical analysis the cure rate of the two periods P> 0.05, suggest the difference has no statistically significant.5. During the trial period, there were no drug-related adverse reactions in patients, the blood test, stool and blood biochemistry (liver and kidney function tests) before and after the treatment are not markedly abnormal changes.Conclusion:The jiajian Wenjing decoction have a good effection on treating primary dysmenorrhea. It can effectively relieve pain and reduce the degree of dysmenorrhea, improve symptoms, and can effectively control the recurrence. The safety of drug are reliable, It worthy of widly applicated in clinical of gynecology.