Relationships Of Epilepsy Of Infants And TORCH Infection

Background:Epilepsy is one nervous system dysfunction syndrome caused by over-syschronous abnormal discharge of brain neurons, and it is the most common form of the primary brain disease, it also is one of the chronic central nervous system disease in childhood..The definition of epilepsy pathogeny is very important to treat epilepsy and judge prognosis.In recent years,the studies of the causes of epilepsy have received great progress,but there are few studies of epilepsy and TORCH infection. Torch infection include the infections of Toxoplasma(TOX),Rubella Virus(RV),Cytomegalovirus(CMV)and Herpes Simplex Virus(HSV)., which could cause many organs and systems infection of infants and may affect nervous system and lead to epilepsy. Human Cytomegalovirus infect developing brain, the infants may exhibit mental retardation, microcephaly, hydrocephalus, deafness and epilepsy at birth. We have had anti-TORCH IgM and IgG detection among epilepsy infants so to analyze the relationships between epilepsy infants and the infection of TORCH.Materials and methodsStudy subjectsThere were 40 patients who were diagnosed epilepsy and were treated in the department of pediatrics in Qilu hospital from January 2010 to September 2010, and there are 23 males and 17 females.The youngest was 4 days old and the oldest was 10 months old.There were 29 patients younger than 6 months and 11 patients mid in 7-12 months.The control group was 30 healthy infants who were the same age with epilepsy patients and who had physical examinationh in our hospital in the same period. MethodsSerum Toxoplasma(TOX),Rubella Virus(RV,Cytomegalovirus(CMV)and Herpes Simplex Virus Type-Ⅰ/Ⅱ(HSV-Ⅰ/Ⅱ)immune antibodies(TORCH-IgM/IgG)) were examined by Enzyme Linked Inmonosorbent Assay(ELISA) in 40 epilepsy of infants and examined in 30 normal infants.All results were analyzed by software SPSS 13.0.Results1. There were 7 patients having positive TORCH-IgM antibody in 40 epilepsy patients.The number of patients with positive CMV-IgM antibodies were 7 and the number of patients with positive TOX-IgM,RV-IgM,HSV-Ⅰ-IgM,HSV-Ⅱ-IgM antibodies was 0. The number of normal infants with positive TORCH-IgM antibody was 0..The positive rate of CMV-IgM immune antibodies in epilepsy group higher than control group. The positive rate of the other TORCH immune antibodies was not higher than control group.2. The positive rate of CMV-IgG(82.76%) in epilepsy patients before 6 months was higher than the patients of 7-10 months(45.45%). The positive rate of CMV-IgM in epilepsy patients before 6 months(20.69%) was not higher than the patients of 7-10 months(9.09%).3. In the forty epilepsy children, the rate of positive CMV infection was 17.5%, the other pathogens in TORCH, was 0.4. All the epilepsy children had abnormal EEG,20 epilepsy children had abnormal CT or MRI. In the CMV-IgM positive children, there was 4 children who having abnomal CT or MRI..Conclusion1. The rate of TORCH-IgG in epilepsy group was not higher than control group. There was no differences in two group.2. The rate of CMV-IgM in epilepsy group was higher than control group.There was different in two group.