Study The Rate Of Intrauterine Infection And The Rate Of Decidua Infection Of TORCH Infection In Pregnant Women

TORCH which includes Toxoplasmosis, Other (syphilis, varicella-zoster,parvovirus B19), Rubella,Cytomegalovirus , and Herpes infections, infect a great deal of people by the investigation of Clinical Epiemiology. They are the most common pathogenic microorganismto cause intrauterine infection in pregnancy women.Most of the TORCH infections cause mild maternal morbidity, but have serious fetal consequences. In mother they are inapparent or asymptomatic and hence difficult to diagnose clinically.Placenta barrier can not prevent transmition of TORCH pathogenic microorganism.Infants may acquire these infections in utero, peripartum,or postnatally, resulting in a variety of clinical syndromes, ranging from asymptomatic infection to severe infection,with high mortality rates and significant long-term morbidity. TORCH intrauterine infections remain important causes of deafness, vision loss, and behavioral or neurologic disorders among children worldwide.Also they are some of the most common infections associated with congenital anomalies. Therefore, recognition of maternal disease and fetal monitoring once disease is recognized are important for all clinicians. It is absolutly necessary to screen TORCH infection of women who had the histories of abnormal pregnancies and who had contacted with TORCH infection sources . Knowledge of these diseases will help the clinician appropriately counsel mothers on preventive measures to avoid these infections, and will aid in counseling parents on the potential for adverse fetaloutcomes when these infections are present.Objective: To investigate the rate of intrauterine infection and therate of decidua infection of TORCH infection in pregnant women.and provide the proovfs for evidence-based medicine to guide the diagnosis and treatment in clinic practice.Methods: The study group consisted of the TORCH-IgM positive cases in blood serum of 132 pregnant women with abnormal pregnancy history.The TOX -DNA,CMV-DNA and HSV2-DNA of fetal chorionic villi and maternal decidua was detected by polymerase chain reaction (PCR).The RV-RNA of fetal chorionic villi and maternal decidua was detected by reversetrascription polymerase chain reaction (RT-PCR).Results: It was found that, TORCH -IgM antibodies of pregnant women with abnormal pregnancy history were positive in 25 cases for TOX ,15 cases for RV ,19 cases for CMV and 16 cases for HSV-2 infections.Among of them there were positive in 11 cases for TOX , 3 cases for RV ,9 cases for CMV and 5 cases for HSV-2 in the detection of all fetal chorionic villis. There were positive in 9 cases for TOX , 2 cases for RV , 8 cases for CMV and 3 cases for HSV-2 in the detection of all fetal maternal deciduas.we compared the distributing of data between two groups. The positive rates between two groups are not differences significantly (P>0.05).Conclusion: The rate of intrauterine infection of TORCH infection in pregnant women are 44.00%(11/25) for TOX,20.00%(3/15) for RV,47.37%(9/19) for CMV,31.25 %(5/16) for HSV. There is a high incidences of intrauterine infection of TORCH infection in pregnantwomen.The rate of decidua infection of TORCH infection in pregnant women are 32.00%(8/25) for TOX,13.33%(2/15) for RV,42.11%(8/19) for CMV,18.75%(3/16) for HSV.There is a high incidences of decidua infection of TORCH infection in pregnant women too. Decidua infection is the important cause of intrauterine infection of TORCH infection in pregnant women.