Studys On The Pharmacodynamics Of Ciwujia Guanxinning Capsule

Ciwujia Guanxinning capsule is Chinese medicine preparations which is made of total flavonoids.The prescription is used for the treatment of coronary heart disease, angina, hyperlipidemia and other diseases. According to its clinical application,the subject was related to its pharmacodynamic experimental research to verify the pharmacodynamic effects of Ciwujia Guanxinning capsule.First, this article through the massive literature, summarized the cause of coronary heart disease, clinical research and treatment.Unifies with the prescription, elaborated the cause of coronary heart disease, the pathogenesis and the govern with the Chinese medicine theory.The article summarizes the pharmaceutical research and pharmacological studies of the leaf of Acanthopanax.The Pharmacodynamics research of Ciwujia Guanxinning capsule including the effects of hypoxia experiment of mice, rabbit hearts coronary flow, pituitrin induced acute myocardial ischemia in guinea pigs and mice impact of Hypercholesterolemia.Though hypoxia experiments, using Diao Xinxuekang as a positive control, atmosphe-ricand vacuum hypoxia conditions, high and low dose group of Ciw-ujia Guanxinning capsule compared with the saline group were signi-ficantly different (p<0.05), can atmospheric pressure significantly prolong the survival time under hypoxia environment and improve the survival rate of mice, suggesting that Ciwujia Guanxinning capsule has hypoxia effect; though coronary artery flow experiments of rabbit were prepared isolated heart by Langendorff, the aortic cannula into the side of each group of drug possession, useing Diao Xinxuekang as a positive control, high and low dose group of Ciwujia Guanxin ning capsule compared with the saline group were significantly different (p<0.05),the result showed that Ciwujia Guanxinning capsule can increase the isolated rabbit hearts coronary flow signi -ficantly;though Pituitrin experimental acute myocardial ischemia, respectively, front-end to the plastic pipe into the ground Austrian health as a positive control efforts to combat drugs ST segment shift and T wave increases as the index, high and low dose group of Ciwujia Guanxinning capsule compared with the saline group were significantly different (p<0.05),the result showes that Ciwujia Guanxin ning capsule has the effect of anti-myocardial ischemia; though experimental hypercholesterolemia in mice, using 75% of the rapid formation of egg yolk emulsion hypercholesterolemic mice serum cholesterol levels were determined by Diao Xinxuekang as a positive control, high and low dose group of Ciwujia Guanxinning capsule and the saline group were significantly differences (p<0.01), the result showes that Ciwujia Guanxinning capsule has the effect of canthopanax significant hypolipidemic;though the experiment of spontaneous activity in mice, useing Ciwujia tablet as a positive control, high and low dose group of Ciwujia Guanxinning capsule compared with the saline group were significantly different (p<0.01), the result shows that Ciwujia Guanxinning capsule can inhibit spontaneous activity, with a sedative effect.