The Pharmacodynamics Experiment Study Of Qi Xuan Yi Xin Capsule In Treatment Of Diabetes Mellitus Acompanied By Coronary Heart Disease And The Effect On Expression Of NF-KB, IL-1β In Myocardium And Pancrea

This thesis summarized comprehensively the progress of pathogeny, pathology, therapy and diagnose of diabet accompanied by coronary heart disease in the area of traditional Chinese medical and modern medical. This thesis also systematically summarized academic idea of diagnose and treatment for diabet accompanied by coronary heart disease by Dr. Linde Li, which was based on the large number of clinical cases. Treatment effect of capsule Qixuanyixin on diabet accompanied by coronary heart disease was observed in vivo. Using the mechanism of capsule Qixuanyixin against diabet accompanied by coronary heart disease was investigated using immunohistochemical and molecular biology technology.(1) The results showed that capsule Qixuanyixin reduced blood glucose, glycosylated serum protein, and blood-fat, elevated Ins. It can significantly improve posterior pituitary induced myocardial ischemia and cardiac function. It can inhibit release of myocardial enzymes. ( 2 ) Capsule Qixuanyixin inhibit the degradation of NF-κB and IκBα, and also inhibit the activation of NF-κB in acute myocardial ischemia of diabetic rat model. The protective effect to acute myocardial ischemia in each concentration was better than Minidiab. The effect of capsule Qixuanyixin in the high concentration was superior to Danshendiwan. Capsule Qixuanyixin could inhibit the degradation of NF-κB与IκB aprotein and the activation of NF-κB in pancreas. The protective effect to pancreas in each concentration was better than Danshendiwan. The protective effect was superior to Minidiab in high concentration of capsule Qixuanyixin. (3) Capsule Qixuanyixin reduced the protein and mRNA products of IL-1βin both myocardial tissue and pancreas tissue in acute myocardial ischemia of diabetic rats model in all tested concentrations. The effect was better than Minidiab and Danshendiwan control in high concentration. (4) Morphology study showed that the protective effects of capsule QiXuanyixin to ischemia myocardial and pancreas in the high concentration were superior to Minidiab and Danshendiwan respectively by HE stain and electro-microscope observation.