The Study On Mechanism Of Chinese Traditional Medicine Treatment By Nourishing Kidney-Yin Of Perimenopausal Syndrome

Perimenopausal syndrome is when women in natural menopause, the hypothalamic-pituitary-ovarian dysfunction caused by ovarian dysfunction. There are some basic Symptoms like autonomic nervous system dysfunction. Modern medicine for the treatment of perimenopausal syndrome is mainly for hormone replacement therapy, although certainly effective, but there is vaginal bleeding, breast tenderness and other adverse reactions, in the long term it is possible that increasing the risk of endometrial cancer and breast cancer. Chinese medicine treatment of perimenopausal syndrome now has achieved good effects. In ancient Chinese medicine for this disease has not a specific disease name in the correspondence, only some of the literature of the treatment of their symptoms, and kidney has been proposed for Basis in growing old. With the development of clinical medicine and the progress of modern technology, modern Chinese medicine makes the Perimenopausal syndrome in kidney-deficiency-based, especially the kidney-Yin deficiency syndrome based. The author organizes the ancient literatures and modern clinical pharmacology and experimental literatures in the treatment of related disorders in perimenopausal women by nourishing Kidney-Yin.The mechanism of the Chinese medicine treatment by nourishing kidney-Yin of perimenopausal syndrome were described in detail from traditional Chinese medicine theory and the modern clinical pharmacology experiments.To study in Chinese medicine theory, the author discusses deeply on the basis of the Chinese medicine treatment by nourishing kidney-Yin of perimenopausal syndrome, the mechanism of action, compatibility of the use, summaries that perimenopausal syndrome is mainly caused by kidney-Yin deficiency, at the same time the disease location Involves the liver and heart. The Chinese medicine of nourishing kidney-Yin are sweet and slightly cold with the medicinal properties of features, they can nourishing organs and clearing deficient heat, mechanism of action is to nourishing kidney-Yin, nourishing the liver and heart, balancing Yin and yang. anti-aging. In clinical they are not only use for Kidney-Yin Deficiency, but also use for Kidney-Yin and Liver-Yin Deficiency, and heart-kidney imbalance.Compatibility of other Chinese medicine of clearing heat, regulating the flow, eliminating phlegm, invigorating the circulation of blood, relieving dizziness, tonifying Yang in treatment of other syndromes of perimenopausal syndrome. As long as the syndrome differentiation with reasonable compatibility, we can correct use of traditional Chinese medicine of nourishing kidney -Yin, avoid being bored of growing the gastric disadvantages nay. To study in modern pharmacology, the author summarizes mechanism of action of traditional Chinese medicine by nourishing kidney -Yin of perimenopausal syndrome, mainly in the improvement of perimenopausal women of reproductive endocrine, neuroendocrine, immune function, anti-aging and so on.In experimental studies, the author uses a female HPX rat model of ovarian dysfunction, observes traditional Chinese medicine MPG's regulation of ovarian function by nourishing kidney -Yin. The results showed that:MPG can increase the growth of HPX rat ovaries to the growing follicle's diameter, the number of corpus luteum, increases the expression of ovarian autocrine/paracrine factor IGF-1 and INHA, regulates of ovarian micro-environment to improve and restore ovarian secretion. The author also detects the expression of oncogenes in ovarian tissue; the results show that MPG did not significantly enhance its expression.