| [Objective] Base on a lifetime of clinical practice and medical successes of a national honored senior TCM Doctor, Professor Zhouzhongying -- also known as a national medical master, using a modern information technology as a means of data mining methods to study his clinical experience and academic thinking of treatment for chronic kidney disease (CKD). In hope to return to improve the clinical treatment for CKD and expand TCM knowledge.[Methods] By closely following Professor Zhouzhongying in a long term clinical practice, collect all the CKD related cases in the past 7 years. The accumulation data are strictly rescreening to meet the standard criteria. The results are 92 cases with 341 clinical follow up. All the clinical data are using SOL-server 2005 software to establish clinical case collections and database storage; moreover, using comprehend frequency distribution, cluster analysis, associated condition to focus on defining and analyzing the core prescription and the association with symptoms and pathogenesis,in the end sum up the result and draw a conclusion.[Results] 92 patients, male 48 cases, female 44 years old, the oldest 80 years old the youngest 9 years old, with an average age of 43.14 years, of which 83 patients with primary kidney disease.Frequency of more than 20% of the symptoms and laboratory tests as follows:dull red tongue, yellow fur, yellow greasy fur, thready pulse, soreness of loins, dry mouth, high serum creatinine, urine protein, urine occult blood-positive, of which the yellow greasy fur frequency of the highest,70.97%; pathogenesis, the pathogenesis of renal-related frequency of 93.26%, dampness-heat, static blood, yin-juries were 58.06%,38.12%,36.95%; the Chinese materia medica used in the frequency of 45% are:indian bread, Phellodendron, Serissa, fresh rehmannia, glabrous greenbrier rhizome, raw milkvetch root, ghost feather arrows, fried atractylodes rhizome, oriental waterplantain rhizome, japanese thistle herb.Clustering method used to obtain the core side 4 categories:â‘ fresh rehmannia, Serissa, glabrous greenbrier rhizome,raw milkvetch root, ghost feather arrows;â‘¡fresh rehmannia, common anemarrhena rhizome,Phellodendron, creeping euphorbia, yerbadetajo herb,rhubarb charcoal, tree peony bark;â‘¢fourleaf ladybell root, coastal glehnia root, figwort root, dwarf lilyturf tuber, fresh rehmannia, Phellodendron, Serissa glabrous greenbrier rhizome, raw milkvetch root, ghost feather arrows creeping euphorbia, yerbadetajo herb;â‘£epimedium herb, Serissa foetida, glabrous greenbrier rhizome,fried atractylodes rhizome, Phellodendron, cablin patchouli herb, perilla leaf, prepared pinellia tuber, golden thread, medicinal evodia fruit, raw milkvetch root, ghost feather arrows. relevance between prescriptions and symptoms,:the set different threshold value range, support and interaction to meet the maximum rate of the combination of prescriptions and symptoms includ fresh rehmannia, yerbadetajo herb, Serissa & dry mouth, indian bread, Serissa, oriental waterplantain rhizome &greasy yellow fur, dark tongue; support a high degree of mutual influence the rate and the maximum value of the square to meet the combination of fresh rehmannia, creeping euphorbia, yerbadetajo herb& frequent micturition, fresh rehmannia, Phellodendron, Serissa & urine foam, fresh rehmannia, Phellodendron, rhubarb charcoal & urine foam, yellow fur, fresh rehmannia, Phellodendron, glabrous greenbrier rhizome,& urine foam, yellow greasy fur, dark red tongue, tthin slippery pulse, fresh rehmannia, Phellodendron, shearer's pyrrosia leaf &yellow urine,fresh rehmannia, Phellodendron lychees grass & soreness of loins, yellow greasy fur.[Conclusion] 1. Disease located in the kidney, involving the spleen and stomach and lung.2. Dampness-heat, static blood,ahd yin-juries,CKD'basic pathological factors, throughout the evolution of CKD are always the key factors in increasing CKD.3. For proteinuria, hematuria, serum creatinine higher,sum of root disease type 4:â‘ dampness-heat stagnating in kidney:the main symptoms are lumbago, soreness of loins, urinary foam, yellow greasy fur, thin slippery pulse, and urine protein, to complement governmentrenal clear benefit, as traditional Chinese medicine prescription, fresh rehmannia, Serissa, glabrous greenbrier rhizome,raw milkvetch root, ghost feather arrows;â‘¡Contact kidney injury and syndrome of stagnant dampness-heat type:main symptoms as lumbago, soreness of loins, dry mouth, yellow and greasy fur, tonguedark red or dark purple, thready pulse or plasma, and urine test positive for occult blood, kidney and governance in order to contact, clearing away heat, cooling blood, as the traditional Chinese medicine prescription, fresh rehmannia, common anemarrhena rhizome,Phellodendron, creeping euphorbia, yerbadetajo herb,rhubarb charcoal, tree peony bark;â‘¢Qi and Yin deficiency of kidney and lung types:primary symptoms as lumbago, soreness of loins, urinary foam, limb swelling, dry mouth, tinnitus, fatigue, yellow or yellow and greasy fur, dark tongue, tonguea crack, thready pulse, urine occult blood positive, urine protein, to nourish the governance focus, clearing the next focus, benefiting Qi and Yin of kidney and lung, the prescription:fourleaf ladybell root, coastal glehnia root, figwort root, dwarf lilyturf tuber, fresh rehmannia, Phellodendron, Serissa glabrous greenbrier rhizome, raw milkvetch root, ghost feather arrows creeping euphorbia, yerbadetajo herbâ‘£spleen and kidney deficiency, dampness and blood stasis gastric loss and drop type:main symptoms as lumbago, soreness of loins, fatiguefatigue, cold, nausea, pantothenic acid, yellow and greasy fur, dark tongue, thready pulse or plasma, and serum creatinine higher governance in order to benefit spleen and kidney, dampness chaotic, and regulating stomach for lowering adverse qi, prescription as epimedium herb, Serissa foetida, glabrous greenbrier rhizome,fried atractylodes rhizome, Phellodendron, cablin patchouli herb, perilla leaf, prepared pinellia tuber, golden thread, medicinal evodia fruit, raw milkvetch root, ghost feather arrows4. traditional Chinese medicine of use:Dry mouth with traditional Chinese fresh rehmannia, yerbadetajo herb, Serissa; frequent urination with traditional Chinese medicine, fresh rehmannia, creeping euphorbia, yerbadetajo herb; urinary foam with traditional Chinese medicine, fresh rehmannia, Phellodendron, Serissa; urinary foam and see if the yellow tongue coating with traditional Chinese medicine,resh rehmannia, Phellodendron, rhubarb charcoal; urinary foam and see yellow and greasy tongue coating, dark red tongue, thin slippery pulse are using traditional Chinese medicine, fresh rehmannia, Phellodendron, rhubarb charcoal; urinary foam or dark red tongue with yellow urine and see traditional Chinese medicine, fresh rehmannia, Phellodendron poison am;yellow urine with a traditional Chinese medicine, fresh rehmannia, Phellodendron, shearer's pyrrosia leaf; lumbago and see the yellow and greasy fur with traditional Chinese medicine, resh rehmannia, Phellodendron lychees grass. Frequently used matching traditional Chinese medicine are resh rehmannia, and Phellodendron,resh rehmannia and yerbadetajo herb,resh rehmannia and rhubarb charcoal Serissa and glabrous greenbrier rhizome,hirsute shiny bugleweed herb and oriental waterplantain rhizome.
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