The Influence Of Dan Huai Yin Xie Concentrated Pill On The Expression Levels Of IL-8 And IL-10 In Psoriasis-Like Lesions Of Guinea Pigs

Objective:To explore the effects of DAN HUAI YIN XIE Concentrated Pill on the Expression Levels of IL-8 and IL-10 in Psoriasis-like Lesions of Guinea Pigs Caused by Propranolol. Explore the mechanism related to the treatment of psoriasis. Provide reliable scientific basis,and for it's extensive application provide theoretical basis.Methods:5% propranolo emulsion was applied on ears back of Guinea pigs to produce the psoriais-like models,then respectively treat with experimental drug. Light microscope to observe the pathological changes of local skin. Tissue lesions detected IL-8 and IL-10 levels by ELISA. Observe the performance levels and the relationship between skin lesions.Results:Guinea pig model of psoriasis induced by propranolol in serum and tissue levels of IL-8 higher than the normal group (P<0.01), IL-10 levels were significantly lower than normal group (P<0.01). MTX group, QINGDAI group and DANHUAN high, medium and low dose groups could effectively reduce the level of IL-8; increased levels of IL-10, significant treatment effect. Compared with the model group were significantly different (P<0.05, P<0.01). Furthermore, the efficacy of the best is MTX, QINGDAI capsule and DANHUAI medium dose.Conclusions:DAN HUAI YIN XIE Concentrated Pill have a therapeutic effect on psoriasis-like lesions of guinea pigs'ears caused by propranolol.and the mechanism may be related to influence IL-8, IL-10 levels, changing the balance of Thl/Th2.