The Empirical Study Of Dhyxnsw's Effect On The Pathological Morphology And TNF-?, TGF-?₁ Of Psoriasiform-Model's Guinea Pig

Psoriasis is a chronic inflammatory dermatosis characterized by erythema and generous scales. As a common disease throughout the world it does great harm to patients'physical and mental health. The aetiology of psoriasis is known incompletely and the curative effect is not very satisfatory. But modern researches have demonstrate that Psoriasis has greatly something to do with heredity, immunologic function dysfunction, infection, inflammation, neuromediator, endocrine, cell proliferation and apoptosis, microcirculation disorder, metabolism, nerve and psyche ,and so on. Psoriasis is the interactive result of genetic factor and environment factor. So far western medicine have certain curative efect on psoriasis but not can do without toxic and side-effect, furthermore, relatpseing is frequent after drug withdrawal. So herb therapy on psoriasis is a prevalence in china and in the world because of the true cure and lower toxic and lower side-effect than western medicine.Psoriasis is a disease of immune disturbance under polygenic inheritance. The fundamental mechanism is the immune incorreted interference. Modern researches have established hyperkeratinization and parakeratosis of keratinocytes and the hyperplasia of the capillary vessel in the dermis as the fundamental pathological changes. Clinically, we apply DHYXNSW to treating Xuerexing-psoriasis (psoriasis vulgaris),and the effect is significant. This study is aimed to observe the effet of DHYXNSW on pathological changes and immune factors associated with psoriasis of guinea pig model of psoriasis-like skin. Through establishing two control groups of Methotrexate and FFQDJN and establishing high, medium and low dose groups of DHYXNSW to treating guinea pig of psoriasis-like model, we investigate the inhibition of psoriatic hyperkeratosis and parakeratosis, and mediating of immune factors of guinea pig of psoriasis-like model and their dose-dependent effects. The results show that DHYXNSW have significant therapeutic effect on psoriasis-like model of guinea pig, and the effects are not significantly correlated with the dose. This study demonstrates that the therapeutic effects of medium, low dose group of DHYXNSW are better than the FfqdJN group but are as good as the Western medicine group in inhibiting the epidermal cell proliferation and promoting their differentiation,inhibiting cytokine involved in inflammatory and immune processes. Effect at high doses is close to FfqdJN group but no better than medium and low dose group, the mechanism needs further study. The study's results of DHYXNSW efffect of the treatment of psoriasis-like model provides with a powerful experimental evidence to the treatment of psoriasis in clinic and play a significantcant role in the rationalization and optimization of clinical programs.