| The morbidity and mortality of coronary heart disease (CHD) in China show continuous increase in the recent years. There is still a long way to go to improve our primary and secondary preventions of CHD. It's of great importance and practical significance that we find the treatment and second prevention of chronic stable angina pectoris with the integrated traditional and western medicine in our country. The topic is about the controlled clinical study on prevention and cure in western medicine group and integrated traditional and western medicine group.ObjectivesThe method of evidence based medicine (EBM) was employed in this study. To observe the efficacy of integrated traditional Chinese and western Medicine treatment on the chronic stable angina through the implementation of the guidelines of secondary prevention of coronary heart disease (CHD) and the combination with the traditional Chinese medicine, in order to decrease the incidence rate of the acute cardiovascular events of the patients with stable angina in traditional Chinese hospital.MethodsThe 51 cases of chronic stable angina patients from the Dongfang Hospital, the affiliate hospital of the Beijing University of Chinese Medicine, were randomly separated into two groups, with the western medicine group to be the control group and the integrated traditional Chinese and western Medicine group to be the treatment group. The treatment of western medicine group completely put ACC/AHA 2002 guideline update for the management of patients with chronic stable angina into practice, and we just use the Chinese lipid-lowering drug Xuezhikang instead of the Statins used in the western medicine group, and to introduce the circulation invigorating drug (such as Fufang Danshen Tablet, or Fufang Chuanxiong capsule or Suxiaojiuxin Pill and/or Shenshao Tablet (Shengmai Yin). It took two years to have observed the incidence rate, hospitalization rate and mortality of the acute cardiovascular events of the two groups. To compare the angina symptoms, withdrawal rate of nitroglycerin, the blood lipid and the changes of traditional Chinese medicine symptoms before and after the experiment.ResultsAdmission rate, acute heart accident incidence rate, mortality rate:The admission rate of treatment group shown 15.38%,the admission rate of Matched group shown 12%,their differences had no statistical significance.The Matched group has no death, and the mortality of treatment group shown 7.69%. Their differences had no statistical significance (P>0.05).Two groups both have no the acute heart accident. Clinical symptoms of angina curative effect:Treatment group shown 88.46%, Matched group shown 92.00%, their differences had no statistical significance (P>0.05).The withdrawal rates of the control group and the treatment group are 28% and 19.23%, which showed no statistic significance (P>0.05). And no increase in the number of the cases was observed in the two-years study.The Total cholesterol, triglycerides and low density lipoprotein showed decrease compared to the situation before the treatment (P<0.05) and the high density lipoprotein showed some increase (P<0.05). There was no significant difference between the two groups on these items (P>0.05)The total effective rate of the improvement of symptoms of the integrated traditional Chinese and western treatment group was 76.9% and the western medicine group showed 52%, from which we could see significant difference, and the treatment group is superior to the matched group (P<0.05)Conclusions1,The integrated traditional Chinese and western medicine treatment of the chronic stable angina showed competitive efficacy compared with the western medicine.2,Xuezhikang showed the same lipid regulation function as the statins.3,The improvement of the symptoms of the integrated treatment had superiority over the western medicine. |
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