The Different Causes Of Pulmonary Fibrosis And Lung Paralysis Correlation Discussion

Objective:From studying the features of clinical manifestations, TCM syndromes and prognosis between idiopathic pulmonary fibrosis (IPF) and interstitial lung disease associated with connective tissue disorder,secondary pulmonary fibrosis(SPF), discuss the dependability among PF of different pathogeny and pulmonary arthralgia to provide ideas for the TCM name and clinical therapia of pulmonary fibrosis disease.Method:The subject applies the way of reviewing study,and collects 114 cases of PF patients classified into idiopathic group and secondary group by the pathogenesis, statisticsing and analyzing the features of clinical manifestations, TCM syndromes and prognosis of PF, and comparing the difference among them.Results:l.Sex and age:At the aspects of sex and age bracket, SPF and IPF have differences by X2 proof-test (P< 0.05). most patients of SPF are women about the age of 50, and most patients of IPF are men older than 70.2.Season of disease:Comparing the season of disease between SPF and IPF, P> 0.05, there is no differences. In two groups, the onset is usually in the Autumn.3.Clinical manifestations:more patients of IPF have the symptoms of lung than SPF, such as pant, gasp, suffocation, cough, expectoration (p< 0.05); meanwhile more patients of SPF have the symptoms of body than IPF, such as joint pain, joint swelling, skin erythema or nodules, skin hardens and muscle pain or weakness in tight (p< 0.05).4.Syndrome:the nature of PF is intermingled deficiency and excess, with Qi and Yin Deficiency inclusion of blood stasis syndromes of the most common syndrome type. Organs in most patients have different degrees of deficiency, and the general performance is a single or a few organs simultaneous deficiency, in which lung deficiency and kidney deficiency have the largest proportion. 5.Evaluation of disease:idiopathic group is prone to suffer from pulmonary hypertension and more severe than secondary group (p< 0.05); with pulmonary hypertension becoming severe, it is more likely to bring about right ventricular hypertrophy (p< 0.005); the patients in idiopathic group have Vecrol rales and clubbed finger more frequently than the secondary group (p< 0.005); In the Pulmonary function testing, TCL, FVC, Dloc of idiopathic group decreased significantly compared with the secondary group.6.prognosis:diopathic group has relatively worse prognosis and high mortality than secondary group (p< 0.05).Conclusion:1.TCM name of SPF and IPF belong to pulmonary arthralgia.2.Patients of SPF are mostly middle-aged females, with the symptoms of body arthralgia and pulmonary existing at the same time, syndrome of deficiency in origin and excess in superficislity. so the treatment of the body arthralgia symptoms and pulmonary symptoms should be balanced.3.IPF is more common to older men. They have less body arthralgia symptoms but more pulmonary symptoms, and the lung function decreased significantly, with severe condition and poor prognosis. so the therapy should focus on how to adjust the organs function of lung and kidney, improve the symptom of pulmonary and prolong survival based.