In Addition To Ma Guixuan Lung Clinical Observation Of Arthralgia Syndrome For The Treatment Of Early Rheumatoid Arthritis Of Wind-cold-dampness Syndrome

Objective: To investigate the Magui Xuanfei Chubi Decoction in the treatment of early rheumatoid arthritis and arthralgia patients is effective and safety. Methods: Ma Guixuan folic acid folic acid methotrexate(Ma Guixuan selected in accordance with the inclusion criteria, 60 cases of wind cold dampness stagnation type of early rheumatoid arthritis patients according to the random number table of random grouping, divided into the treatment group and lung Chubi Decoction) and control group(MTX), each group of 30 people, with a course of 3 months, respectively, were observed and recorded in the two groups before and after treatment of TCM clinical syndrome integral, laboratory tests and treatment of TCM clinical efficacy evaluation, TCM syndrome integral, DAS28 index, disease curative effect evaluation and objectively reflect the adjuvant used lung Chubi Decoction in the treatment of early stage rheumatoid arthritis arthralgia due to wind cold dampness stagnation type in patients with clinical curative effect and safety. The obtained data using spss21.0 software statistical analysis. Results:1. After treatment, the total effective rate of the treatment group was 86.67%, and the total effective rate of the control group was 73.33%, and the difference was statistically significant(P<0.05).2. Two groups before and after treatment, compared with the single symptom score, the difference was statistically significant(P < 0.05); the two groups of patients with clinical symptoms and signs after treatment were significantly improved, the difference was statistically significant(P < 0.05).3. After treatment, the total score of TCM syndromes in the two groups were compared, the difference was statistically significant P=0.008 < 0.05), the difference was statistically significant(P<0.05) between the treatment group and the control group.4. After treatment, the difference of DAS28 score between the two groups was statistically significant(P=0.04 < 0.05). After treatment, the disease activity of the two groups was compared, and the difference was statistically significant(P=0.028, P < 0.05).5. The two groups of patients after treatment laboratory indicators CRP, ESR were significantly decreased, the difference was statistically significant(P<0.05), but the difference was not statistically significant(P > 0.05) before and after RF treatment.6. After treatment in the two groups of disease curative effect comparison, the treatment group, the total efficiency =93.3%. In the control group, the total efficiency of =73.3%, difference was statistically significant(P = 0.038, P < 0.05).7. The incidence of adverse reactions in the two groups after treatment was compared, the incidence rate of adverse reactions in the treatment group was 10%, the incidence rate of adverse reactions in the control group was 23.33%, the probability of adverse reactions was quite different, and the difference was not statistically significant(P=0.166 > 0.05). Conclusion:Early rheumatoid arthritis wind cold dampness arthralgia in patients with MTX combining Magui Xuanfei Chubi Decoction in treating effect has superiority. Not only can improve the symptoms and signs and reduce the patients with CRP, ESR level, and the security is good.