Rebi Experimental Study Of Particle Treatment Of Rheumatoid Arthritis

ObjectiveThe Rheumatoid Arthritis(RA) is one of chronic diseases which serious threat the health of the public in the current world extent with degradation of the extracellular matrix and destruction of the architecture and function of joint.The disease is one kind of refractoriness autoimmune disease with complex nosogenesis,and mechanisms of it are complicated now.Histoolgically,hyperplasia of the synovial lining ceils,an inflammatory cell infiltrate composed of lymphocytes and histiocytes with scattered plasma cells and granulocytes and destructive changes of connective tissue and cartilage are seen.Synovitis is a critical pathological change and the major problem of synoviocytes hyperplasia induced by cell apoptosis disorder can lead to lasting immunological reaction of synovitis.Until now there is still no effective and little-toxic side effect medicine in treating RA.RA belongs to "Be sydrome" in TCM,which has unique understandings of the etiology and pathogeneticology of RA and has created a lot of effectual prescriptions in practice.Modern medicine has a lot of problems in the treatment of the disease. Traditional Chinese Medicine(TCM) has potential superiority to cure it.Infusion of ReBi granule is utility recipe to Beriberoid Pyretic Arthralgia(RA) in the fundament of the change plus minus through so many years clinical experiences.This issue is investigation object of Infusion of Re Bi granule,and takes the RA as the investigation cut-in point,and makes deeply investigation to the recipe in the contribution of antiinflammatory and antipyretic,and mechanism of action of treatment of RA.MethodsMake SD maleness rats Adjuvant-Induced Arthritis(AA) which were derived by Freund's complete adjuvant as investigation object. Make Wang Bi granule as positive control medicine,and divide it into groups.Observe Re Bi granule's on the primary role in disease treatment,on the role of secondary prevention of disease,and on the heat of the antipyretic effect in rats.Pharmacology to experiment and explore its mechanism.ResultsRe Bi granule have better AA-induced inhibition of paw swelling in rats.It can be better inhibited secondary lesions in AA rats, to reduce the extent of lesions.The Re Bi granule group have a good therapeutic effect than the control group.Re Bi granule have better antipyretic effect,can significantly reduce the extent of lesions. with time of extension,the Re Bi granule group have a good therapeutic effect than the control group.ConclusionRe Bi granule can be improved rat model of rheumatoid arthritis symptoms,For the treatment of primary lesions have effect and on the secondary role in disease prevention.Re Bi granule is the treatment of rheumatoid arthritis effective drug.