| This topic uses the collagen arthritis big mouse (CIA) to take the animal model, analyzes bi tong ling pellet according to its composition medicine effect for relieves sickness eliminates the wet medicine group, heats after disperses the medicines to treat fever group, invigorates the blood to remove extravasted blood the medicine group and the expectorants group, the observation rheumatism pain works the entire side and four medicines groups to the model big mouse' s foot swelling, the body weight, grades and the pathology influence, discovers the main function medicine, and works entire side through rheumatism pain and four medicines groups to the model big mouse blood incorruptible and unbending CII immune body level, the spleen lymphocyte shifts and its is induced IFN-γ, IL-10, NO, releases MMP the research, further discusses its action mechanism, in order to develop the highly effective high quality Chinese native medicine new medicine to provide the scientific basis.This experiment indicates that bi tong ling pellet can obviously restrain CIA big mouse' s primary and secondary foot swelling. This makes know that bi tong ling pellet have all-right action of contradicting urgent inflammation and restraining immunity. Histoolgicaily, hyperplasia of the synovial lining cells, an inflammatory cell infiltrate composed of lymphocytes and histiocytes with scattered plasma cells and granulocytes and destructive changes of connective tissue and cartilage are seen. On the basis of above, we have investigated the molecular immunological mechanism about bi tong ling pellet against CIA. The experimental results showed that bi tong ling pellet could suppress the transfer of activative T lymphocytes, control the activative T lymphocytes release NO, MMP-2, 9, falling IFN-γ, heightening IL-10 and reduce abnormity heightened anti-CII antibody in the CIA big mouse' s blood... |
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