| ObjectTo observe Zhengqingfengtongning injection on the treatment of mice arthritis model induced by collagen and injection stimulation,dicuss the mechanism of action and provide experimental evidengce for clinical therapeuthy.Method arthritis model was made by IntraarticularⅡtype collagen injection,in the same time,detecting knee joint swelling and.body pathography before and after administration.At the end of experiment,the infusion of mice joint were collected for for measuring activity of TNF-α,IL-1βand content of PGE2,also pathologic examination articulatio genus。the infusion of joint of rabbit stimulated were gathered for rutine inspection,observed disection appearance and took for pathologic examination after diverse injecting joint.Result Intraarticular Zhengqingfengtongning injection can delieve joint swelling.ameliorate the damaged articular cartilage.delieved inflammatory cell infiltration of knee joint and adjusted the cytokine content.Intraarticular Zhengqingfengtongning injection below 1 time per 2days had no obviouse stimulating,but too frequent stimulating can conduce cavitas articulation aggradation and stimulating untoward reaction.Conclusion Intraarticular Zhengqingfengtongning injection have more treating action to mice arthritis model induced by collagen.Its adaption was safe at the clinical recommened dose. |
